They are. There's been no demonstrable link between them and cardiac health.
Again statins increasing life span ... wow its quite simple
They are. There's been no demonstrable link between them and cardiac health.
HDL and LDL ARE NOT THEORETICAL FFS are you retarded
HDL looks like this:
http://www.scielo.br/img/revistas/abc/v87n5/e18f1.gif
LDL looks like this:
http://healthyprotocols.com/image_LDL.jpg
They have a very important role in the body
So? insulin has an important role but if you dont take things in the right context then its as good as understanding absolutely nothing ... you an example of this.
"insulin shock a hypoglycemic reaction to overdosage of insulin, a skipped meal, or strenuous exercise in an insulin-dependent diabetic, with tremor, dizziness, cool moist skin, hunger, and tachycardia, sometimes progressing to coma and convulsions." - shall we say insulin is dangerous now ? rofl what a clown
You can't just lower them and expect no effect
Its abnormally high, it must be lowered. This is amazing that something as simple as this escapes you, maybe not. Its like saying "oh your blood pressure is 220/180 there must be a reason for this, the body is doing it we dont need to lower it now there is not hard evidence relating to death from it" .... and no there is an effect, its cardioprotective and prevent plague formation on the arteries.
like this:
http://www.umm.edu/graphics/images/en/18031.jpg
Just like technically no one as actually died directly from HIV infections no one dies directly to high blood pressure or high cholesterol. They get heart attacks or cerebral vascular accidents. BRING THE EVIDENCE ROFL
justify a flawed hypothesis
The survival rate and increase of human life span speaks for itself. Doesnt matter what you think.
It could rise in accordance with disease
There we go slowly you understanding. It does (refer to plague formation above), this is what statins do they block the formation of these LDLs by blocking HMG-coA
Diseases often progress slowly as well
Hence chronic treatment with statins
It's a bad indicator of risk then.
nope. Over 70s doesnt prove a thing because most of your CVD mortality will occur between 50 - 60 ... they already dead.
What about "...were not associated with a significantly higher rate of all-cause mortality, coronary heart disease mortality, or hospitalization for myocardial infarction or unstable angina..."?
I seems to look at more than just 2 parameters.
Because you have no idea what that actually means Dr Swa LOL
"Our findings do not support the hypothesis that hypercholesterolemia or low HDL-C are important risk factors for..." and even the title "Lack of Association Between Cholesterol and..."
again published 1994. Utter rubbish
Statins reduce inflammation
This is NOT the MOA of a statin drug
If their effect was due to lowering cholesterol then why didn't the older classes of cholesterol lowering medication have the same effect
They did. Simvastatin ? where do you get this nonsense from ?
Statins also have other side effects so high cholesterol doesn't justify their use.
Are you insane ? name one side-effect of a statin without googling it. Tell me the frequency of these side-effects. There are enough people on statins and they doing just fine. They would be dead without them. The rationale of statin use in dislipidemia is justified that is not for debate.
Next you going to say the use of beta-lactam antibiotics is not justified because of the anaphaltic shock side effect rofl
It also has a protective effect even if cholesterol is already low or normal. Explain THAT.
HMG-coA reductase. quite simple actually. It doesnt remove cholesterol like antibiotics kill bacteria. It blocks the biosynthesis.
The cancer issue is from a review by Thomas Newman and Stephen Hulley on the effect of statins and fibrates in rodents.
http://www.ncbi.nlm.nih.gov/pubmed/8531288
Yup. Published 1996. Sorry my statin information is 2012 from oncology journals (more than one). I will stick to them. They know more than Dr Swa
So you have to treat about 28 in order to prevent 1 death in the presence of existing heart disease.
Go and learn how clinical trials and studies work and whats the objective of these studies. The randomize clinical trial is done to show activity. Again you looking at the wrong figures Dr Swa:
" Over the 5.4 years median follow-up period,
simvastatin produced mean changes in total cholesterol, low-density-lipoprotein cholesterol, and high-density-lipoprotein cholesterol of
-25%, -35%, and +8%, respectively,
with few adverse effects."
now this is ancient study publish in 1994 fair enough its valid, but go an look at atorvastatin. Its potency is 2 fold. Though what its telling you is that simvastatin was successful in decreasing morbidity and mortality.
More than 40 trials before the inception of statins showing no correlation between low cholesterol and heart health
so? if your cholesterol is normal then there is no need to prescribe a statin. If your cholesterol is high then brought down with use of a statin thats a different story.
It also found cholesterol decreasing with age, an astonishing fact as heart disease goes up with age
Maybe to you. Its called arteriosclerosis. The vasculature loses its elasticity. At the rate you going Dr Swa we should rewrite all the medical guidelines IN THE WORLD

next you will tell me that use of asprin is not necessary in diabetics
yup thats all you can do. Same with evolution. Debating with you is a waste of time. You cant even appreciate time as a factor for scientific research, nor context of material or even the study types.
There is no extreme toxicity to Vitamin D
Funny. I guess I should take down our Vitamin D toxicity guidelines in the hospital. Thanks for telling me this information Dr Swa, we've been doing it wrong all long. To think all those babies we saved, and the elderly who take it for arthritis, guess that was just a fluke. Do me a favour Dr Swa please email all the medical school in SA about this we need to remove it from literature ROFL. Please email UCT school of pharmacy and pharmacology they need to edit the toxicity out of the SAMF. While you at it CC it to the FDA.
Vitamin D is safe, when achieved via natural means, synthetic supplementation of its analogues and itself in solution - thats a different story. Just like ethanol huh, perfectly safe when your body produces it, not so safe when you drink 2 bottles.
effects are far more beneficial with less side
Ok Dr Swa, the entire medical profession is wrong. Why have we been wasting our time with statins. Are you going to tell me vitC is the fountain of youth next ? OR vitB12 cures HIV ? they vitamins.... go an learn what they do first.
Cholesterol has nothing to do with it
Loss of elasticity and plague formation, keep up with these things.
http://en.wikipedia.org/wiki/Arteriosclerosis
http://en.wikipedia.org/wiki/Atherosclerosis
but no proper long term study has been done
Hmmm and I wonder why that is. Just because you have a question that does not mean its a valid avenue. Thats because the theory is utter rubbish.
Save the money spent on dangerous drugs and special diets and buy some supplemental D instead.
LOL anyone reading this dont take this nonsense advice. When Dr Swa ages he will be on a statin or he wont live very long.
To artificially decrease cholesterol through statins and other drugs is dangerous if the body needs to make Vitamin D
Hmmm, a
possible vitamin D deficiency or no blood to my heart .... which is more important I wonder
Thanks Dr Swa this has been so educational. Now im tired of you arguing for the sake of it. You carry on in your world of Vitamins curing CVD and evolution being imaginary and not believing in drug resistance and a man in a table cloth running on water ....
As for me I will still dose patients with lipitor and crestor and keep them alive for 20 years more. Anyways natural selection will remove you one day.