Abstract Title:
Difficulties in eliminating measles and controlling rubella and mumps: a cross-sectional study of a first measles and rubella vaccination and a second measles, mumps, and rubella vaccination.
Abstract Source:
PLoS One. 2014 ;9(2):e89361. Epub 2014 Feb 20. PMID: 24586717
Abstract Author(s):
Zhifang Wang, Rui Yan, Hanqing He, Qian Li, Guohua Chen, Shengxu Yang, Enfu Chen
Article Affiliation:
Zhifang Wang
Abstract:
BACKGROUND: The reported coverage of the measles-rubella (MR) or measles-mumps-rubella (MMR) vaccine is greater than 99.0% in Zhejiang province. However, the incidence of measles, mumps, and rubella remains high. In this study, we assessed MMR seropositivity and disease distribution by age on the basis of the current vaccination program, wherein the first dose of MR is administered at 8 months and the second dose of MMR is administered at 18-24 months.
METHODS: Cross-sectional serological surveys of MMR antibodies were conducted by collecting epidemiological data in Zhejiang province, China in 2011. In total, 1015 participants were randomly selected from two surveillance sites. Serum MMR-specific immunoglobulin G levels were tested by enzyme-linked immunosorbent assay. The geometric mean titers and seroprevalence with 95% confidence intervals (CIs) were calculated by age and gender. Proportions of different dose of vaccine by age by vaccine were also identified. Statistically significant differences between categories were assessed by the Chi-square test.
RESULTS: Over 95% seroprevalence rates of measles were seen in all age groups except<7 months infants. children aged 5-9 years were shown lower seropositivity rates of mumps while elder adolescences and young adults presented rubella seroprevalence. especially, was significantly in female than male. nine measles cases unvaccinated or unknown vaccination history. among them, 66.67% (6>
CONCLUSIONS: A timely two-dose MMR vaccination schedule is recommended, with the first dose at 8 months and the second dose at 18-24 months. An MR vaccination speed-up campaign may be necessary for elder adolescents and young adults, particularly young females.
Article Published Date : Dec 31, 2013
Study Type : Human Study
Additional Links
Diseases : Measles : CK(278) : AC(8), Mumps : CK(41) : AC(1), Rubella : CK(54) : AC(4)
Additional Keywords : Vaccine Failure : CK(244) : AC(30)
Anti Therapeutic Actions : Brachytherapy : CK(10) : AC(1), Vaccination: Measles : CK(157) : AC(16), Vaccination: Mumps-Measles-Rubella (MMR) : CK(228) : AC(26)