Do you think LSD has any benefits?

[RiaX]

You can put anything on a stamp, its just a fun away of giving the thing. Sublingual route it just has to be in the mouth, but I dont know if you can do DMT S/L I was just theorising

 

[Synaesthesia]

Psilocybin would have to be a dose of 10-20mg, which wouldn't fit on a stamp. It would have a strong bitter taste. Effects are similar to LSD, but not quite the same. Not as stimulating nor as long lasting, about half as long.

 

[Sherbang]

So, how they tell the difference from say DMT or extacted psilocybin, or a simple reconstitution of lab grade serotoinin?

Leave that what about the placebo effect >.<

The experiences are similar but different, you can easily tell them apart.
The problem is you haven't tried these substances so you don't realise how distinctive the experiences are.
Placebo cannot produce the effects of an LSD experience. Not a chance...
Techne talks about being 'spaced out' like he knows what that means. What do you mean by 'spaced out' Techne, describe the experience... I haven't done any psychedelics for over 10 years now, so it's hardly habit forming and there is no evidence that it damages your mind in any way.

 

[Sherbang]

Difficult scenario... Trust the subjective opinions of people invested in trying get all spaced out or people with actual scientific training and knowledge...

In many cases Techne, the people 'trying get all spaced out' are the people 'with actual scientific training and knowledge'.
It's not either, or - often it's both. A scientist without a curious mind is never going to discover anything new.
There appears to be a taboo against experimenting with states of consciousness, like it's not real science or has no value. Fortunately this is changing...

 

[Sensorei]

DMT is nothing like LSD or psilocybin. The trip is really short and waaay deeper than acid. You have no idea you are even human when you're on a DMT peak.

 

[Unhappy438]

You can put anything on a stamp, its just a fun away of giving the thing. Sublingual route it just has to be in the mouth, but I dont know if you can do DMT S/L I was just theorising

Yes you can but i don't see how it can be done whilst fooling people that its lsd. Also ingesting dmt isn't that effective from what i know, i dont know much about dmt though so i could be wrong.

 

[Synaesthesia]

So, how they tell the difference from say DMT or extacted psilocybin, or a simple reconstitution of lab grade serotoinin?

Ingesting Serotonin will do nothing to you. Same with DMT, they are both broken down by MAO. DMT taken with a MAO inhibitor is orally active (Ayahuasca)

@ (the other person forgot the name -.-)Secondly there is no such thing as pure LSD on the streets. You know how much a solvent purifier costs to purify on a large scale? is in the millions and leave the amount of the electricity it uses. To give you an idea most chemistry departments in universities in south africa can only afford ONE.

This is not true. It's relatively easy to make drugs. You don't need to make LSD on a large scale. How did Albert Hoffman then make LSD with his simple laboratory in 1943? Tests show most LSD tabs are pure.

 

[RiaX]

ALbert Hoffman worked for a massive pharmaceutical company ?

MAO in found in the synaptic celfts of neurons and has nothing to do with oral ingestion. Your sight is some what inaccurate with regards to SSRIs. You do get orally available 5-HT agonists, however oral 5-HT itself I dont think so, again was theorising

 

[Synaesthesia]

ALbert Hoffman worked for a massive pharmaceutical company ?

Well true. But Shulgin did it at home, sure he's an experienced chemist but no super expensive equipment needed.
http://www.erowid.org/library/books_online/tihkal/tihkal26.shtml

Of course you have to procure erogtamine tartrate and diethylamine which are controlled substances, so that's quite tricky.

But we digress, another interesting point is the amazing high doses of LSD and other psychedelics which the body can handle. My friend was telling me the other night about a 2100ug trip (21 doses of LSD), and I've read many other accounts of ridiculously high doses, even far beyond that, with seemingly no ill effects.

 

[Synaesthesia]

MAO in found in the synaptic celfts of neurons and has nothing to do with oral ingestion.

That may be true, in which case I've learnt something new. I don't know much about physiology and pharmacology, but I do know that DMT needs to be taken with an MAO inhibitor to be orally active. It can be smoked or injected without a MAO inhibitor.

 

[scudsucker]

ah the typical fool that claims "it didnt do this to me so your journals, textbooks, and case reports must be all incorrect and invalid"

Penicillin doesnt kill me anaphalatic shock its a hoax!!! its a conspriacy I tell you.

Go back a few pages to the videos, and ACTUALLY read REAL JOURNALS or STFU and GTFO

I am just asking you, in your "expertise" for scientific proof of your claims, or, at least, published research in the area. Which you have omitted to supply.

Without that, your word on the psychedelic experience is as good or bad as mine: just hearsay.

Oh and "...and ACTUALLY read REAL JOURNALS or STFU and GTFO" - very mature response.

 

[RiaX]

I put up a very fair documentry that is scientifically sound. Techne posted a journal article or two. Ive referenced many processes in human physiology. Im not going to repost things because you to lazy to look back

 

[RiaX]

That may be true, in which case I've learnt something new. I don't know much about physiology and pharmacology, but I do know that DMT needs to be taken with an MAO inhibitor to be orally active. It can be smoked or injected without a MAO inhibitor.

HMmm interesting, didnt know this perhaps the DMT is subject to an extensive first pass effect.

But we digress, another interesting point is the amazing high doses of LSD and other psychedelics which the body can handle.

Yes LSD has a very safe LD50 profile. You need somewhat of 15mg (not mcg) to actually experience toxicity due to the drug however that doesnt mean an adverse effect will not occur at normal doses. People suffer more from side effects from normal pharmaceuticals than street drugs? do you know why? placebo effect. A drug dealer doesnt give you a package insert to read with potential side effects. Never underestimate the placebo effect its damn powerful

 

[scudsucker]

I certainly do not discount the placebo effect, but I fear you do not grasp the real effect of powerful psychedelics.

There are plenty of supposed side effects related to LSD. A common one is sore muscles, attributed incorrectly to "rat poison" added to the tab "to make it stronger". Any hippy will expound at length on the possible side effects.. which are almost all imaginary or "common wisdom".

Therefore, anyone who is exposed to this "common wisdom" may experience placebo side effects in the same way - using your example - that someone reading the package insert may experience placebo side effects.

However, these placebo side effects are not common. Real side effects are extremely rare.

 

[Synaesthesia]

I put up a very fair documentry that is scientifically sound. Techne posted a journal article or two. Ive referenced many processes in human physiology. Im not going to repost things because you to lazy to look back

Well stop making claims like "most LSD on the street is not pure" without evidence.

Next you can BOOST LSD by adding in what is called an SSRI

You can't make that claim without some evidence. I've researched it and what you claim is not true.

You asked earlier in the thread what the exact mechanism of action of LSD is in the brain, and when I said it wasn't well understood you rejected that, even though it's a well-accepted medical fact.

The point is please don't make as if you know everything and lord it all over us.

People suffer more from side effects from normal pharmaceuticals than street drugs? do you know why? placebo effect

Really? That's a very broad claim. The placebo effect sure is interesting, and what you're saying may have some validity: one's expectation plays an important role in subjective effects, but there's just to much variability in substance and dose to make that claim.

 

[RiaX]

Well stop making claims like "most LSD on the street is not pure" without evidence. .

I can guarantee you my entire degree it isnt.

Like shady backdoor medicine, it works but its dangerous

 

[scudsucker]

I can guarantee you my entire degree it isnt.

Like shady backdoor medicine, it works but its dangerous

Would you like to link to a cite showing the toxic and/or harmful additives/byproducts present in LSD sold to the public?

 

[Synaesthesia]

I can guarantee you my entire degree it isnt.

Like shady backdoor medicine, it works but its dangerous

MDMA often, isn't pure. Cocaine, most of the time, isn't pure. Heroin sure as hell ain't pure. But LSD, as I've explained, there's no reason to cut it with anything. It's only 80-100ug. There's a chance it might be something else, like DOB, but that's quite rare, especially these days. Sure if you have any 2nd thoughts then don't do it, I've decided to though.

 

[Unhappy438]

Ok im just going to say what everyone is thinking , i dont think Riax has the expertise that he claims to have. He has made too many incorrect statements in the last few pages.

 

[copacetic]

I haven't seen a shred of evidence presented in this thread, that LSD from a drug dealer is dangerous...