HIV is making coronavirus variants more likely in South Africa

"D"

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The world’s biggest number of HIV cases is complicating South Africa’s efforts to fight the coronavirus pandemic
Yes, more anti SA articles please.
They should consider that it is also a matter of concern for just about all of our neighbouring countries, so it is more like Southern Africa that is more disproportionally affected than other parts of the world, perhaps.

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But then again, the Russian federation has more than 1 million adults living with HIV/AIDS.
 

The_MAC

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1 possibility


Oh no, not another "Ivermectin" equivalent Tenofovir thread incoming..
 

Moto Guzzi

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No body is immune from criticism , especially experts, its whats meant to keep them in check.

Imagine the chaos if everybody just blindly followed what the experts said, Oh wait .........:unsure:

100% agree, you do not need to be an expert to critisize an "educated expert" and the simple reason is if you can detect that the "deep knowledge" might take you in the wrong direction or even harm you, or is confusing in testring, proving & results or Symptoms, and lets face it, success can be claimed over various periods of time, but in the end Mr TIME wins and reveals the real truth, sometimes it take more than a generation, sometimes quicker, as I said before our own short lifetimes of below 100 years is our worst enemy, we just do not learn from experience that well to carry it over to next generations, each generation rejects the previous one and fall in similar traps all over, blasting a load of non renewable resources in the process as well.

If we would get to 500 years old with an active life of 400 years, by this time most problems would have been sorted, simply because each EXPERT wil have to literally sit through his claimed success for 400 years + up to 100 in retirement. This scenario will force out real experts that stood the test of time. I would like to see politics, Digital & Financials here doing their thingies.

Time and successes claimed:
Immediately=Great joy and fanfare & parties, the expert is on fire + his followers.
Short Term=Great joy and fanfare & parties, the expert is on fire + his followers.
Medium Term=If it lasts till here it starts to look good.
Long Term=If it last till here its probably maybe good enough.
For centuries to come over generations=If it makes it past here It is excellent.

So if you are an educated expert, where do your selution stands on the charts of Mr Time-?
 

Mirai

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Pretty much summarises what the prof has been saying for months. He has consistently pointed out that in SA the immunocompromised members of the population is where they think the most mutations are arising. The HIV infected persons form the bigger group.
The evidence has been building up over many months.
I agree the article is terrible however.

It's not the HIV infected per se. It's the HIV infected either not yet on treatment, defaulting treatment or failing treatment. When the patient mentioned by Tulio was given proper ART, a dolutegravir based regimen, she suppressed quickly her HIV and very quickly cleared the covid-19 afterward.

So it's essentially HIV+ and one of 3,

1. Not yet on treatment.
2. Was on treatment and stopped.
3. Has resistant HIV and HIV levels are high.

But HIV on treatment is OK and not a problem. Early HIV is also mostly not a problem if starts treatment ASAP.

Gov is moving to test and treat point of care strategy. You get tested and you start the single pill TLD regime on the same day. The side effects with this are basically nil.
 

Mirai

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Note also that it need not be HIV immunosuppression. People with primary or secondary (chemo, autoimmune disease, cancer, corticosteroids) can also harbour COVID-19 for longer and it can adapt more to their relatively weaker immune responses. NOT ONLY HIV. This is an SA article.
 

Daveogg

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It's not the HIV infected per se. It's the HIV infected either not yet on treatment, defaulting treatment or failing treatment. When the patient mentioned by Tulio was given proper ART, a dolutegravir based regimen, she suppressed quickly her HIV and very quickly cleared the covid-19 afterward.

So it's essentially HIV+ and one of 3,

1. Not yet on treatment.
2. Was on treatment and stopped.
3. Has resistant HIV and HIV levels are high.

But HIV on treatment is OK and not a problem. Early HIV is also mostly not a problem if starts treatment ASAP.

Gov is moving to test and treat point of care strategy. You get tested and you start the single pill TLD regime on the same day. The side effects with this are basically nil.
Reydin for the win.

Was thinking and its pure speculation, but what is the selective pressure on the virus already infecting an immunosuppressed host. I would think selection would be against virulence, as increased virulence would either kill the host or make them seek treatment. Perhaps its not all gloom.
 

Mirai

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Reydin for the win.

Was thinking and its pure speculation, but what is the selective pressure on the virus already infecting an immunosuppressed host. I would think selection would be against virulence, as increased virulence would either kill the host or make them seek treatment. Perhaps its not all gloom.

Alas we are starting to see DTG resistance in SA already. TBH is following this closely.
 

Geoff.D

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Alas we are starting to see DTG resistance in SA already. TBH is following this closely.
Assume the gobbledygook refers to resistance to the HIV treatment drug Dolutegravir? The Prof also mentioned that in his discussion a few weeks ago.
 

Geoff.D

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While on the subject of HIV, a few years ago there was talk of a community in SA (can't remember where) that somehow had a natural resistance to HIV?
 

Seven_Nine_Eight

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HIV doesn't seem to be as high a risk factor even in hospitalisations:
View attachment 1148252

Deaths,
View attachment 1148262
I genuinely thought people with HIV were going to be disproportionately affected by COVID. I have heard or read (can't remember) that a possible reason why this did not turn out to be the case is the low CD4 counts in people with HIV. This in turn will have the effect of dampening the immune response in COVID infected HIV people and prevent possible cytokine storms that are seen in many hospitalized COVID patients and people that die due to COVID infection.
 
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Mirai

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Assume the gobbledygook refers to resistance to the HIV treatment drug Dolutegravir? The Prof also mentioned that in his discussion a few weeks ago.

Yes Integrase inhibitors have revolutionised HIV care. Not just in terms of treatment and few side effects and strength, but also because we can now use 1 or 2 monthly injectibles to treat and prevent HIV. Additional promising drugs are coming along too.
 

grok

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Hmm, if AIDs grabs you now for the long sleep, does it mean a tick for Covid or one for Mbeki?

Gotta keep the counts accurate for prosperity..
 

BBSA

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While on the subject of HIV, a few years ago there was talk of a community in SA (can't remember where) that somehow had a natural resistance to HIV?
In early 2000, researchers discovered a small group of sex workers in Nairobi, Kenya who were estimated to have sexual contact with 60 to 70 HIV positive clients a year without signs of infection
 
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