The way this was explained to me: you have giraffes with long neck (mild strain) and you have zebras with short necks (severe strain). You also have 90% of food source at height and you have 10% of food source at low level. Without giraffes consciously trying to grow long necks, they just have environmental advantage by simply being the way they are. Their numbers would continue to expand due to food available.
Zebras could survive, but their numbers would be minimal in nature. In time they would get overrun by giraffes.
Now imagine you put in place a glass ceiling (lockdown) that prevents giraffes with their long necks (mild strain) reaching the source of food at height (healthy people). All of a sudden, zebras have advantage and will begin to thrive through no other means, but the change in the environment. They did not consciously decide to mutate, it's the environment that has given them the advantage.
And lastly, yes a severe strain can take hold and wipe everybody out, but this would most likely have already hapenned by now (unless we keep putting up glass Ceilings).