- Oct 6, 2018
The LD50 (dose that is lethal for 50% of the population) of ivermectin is 29,5 mg/kg body weight for mice, and 10 mg/kg for rats, see https://go.drugbank.com/drugs/DB00602.I did not even bother with looking at any affiliations --- The way the trial was setup and the so-called objectives already showed the built-in bias that existed.
Go and pick a dosage that is way lower than that already shown on other studies in the World as required to exhibit anti-viral properties and then say " You see, it does not work".
The normal dosages for treating parasites varies from 150 mcg/Kg to 400mcg/Kg depending on the type of parasites being treated.
Other papers have shown that a 100 fold increase is required so why fiddle around at 300mcg/Kg?
The 100-fold dose increase that you are proposing would hence be in these LD50 ranges.
The 100-fold dose increase that you are referring to was used in vitro, not in actual humans.