LinkEpstein was arrested in New York and will appear in court on Monday, law enforcement officials told US media.
It comes amid renewed controversy over a plea deal he once reached to end a federal investigation against him.
His lawyer has not yet commented on the latest charges.
Law enforcement officers have not been authorised to discuss the case, but several have spoken to US media outlets on condition of anonymity.
One told The Associated Press news agency that the latest charges stemmed from allegations that Epstein paid underage girls for massages and molested them at his New York and Florida homes.