Not sure what you mean, but I have both and had no "corruption". It does flag vulnerabilities in MS products though.I ran Kaspersky in 2007. I had to uninstall Comodo and Spybot to install the darn thing, it wouldn't let me install with these on. This year's version also corrupts MS Office 2007.
I'm with BitDefender for AV, Comodo for Firewall, FireFox for Browser and Spybot to cover some holes. My ISP scans my email with AVG so I have double protection for incoming email too.
It's also quite common to get an AV package that doesn't get along with another, especially one that has a comprehensive suite of functions.