Nanoscale Dynamics of LSD1: Epigenetics and anticancer

[Techne]

Interesting research on LSD1 and its relevance to epigenetic-related mechanisms associated with cancer.

Molecular 'Movies' May Accelerate Anti-Cancer Drug Discovery

ScienceDaily (Aug. 16, 2012) — Using advanced computer simulations, University of Utah College of Pharmacy researchers have produced moving images of a protein complex that is an important target for anti-cancer drugs. This advancement has significant implications for discovering new therapies that could attack cancer without damaging the DNA of healthy cells, according to an article published July 31, 2012 in the Proceedings of the National Academy of Sciences

Some movies here.

The article in PNAS:
LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition

Pretty awesome molecular simulations that demonstrate the importance of protein flexibility in docking studies.

 

[RiaX]

hmmmm I wonder what would happen if all cancers were cured.....

 

[empirex]

hmmmm I wonder what would happen if all cancers were cured.....

The drug companies would invent a new cancer

 

[Techne]

hmmmm I wonder what would happen if all cancers were cured.....

Cancers arise due to fitness differences in somatic cells (i.e. evolution). That is why they are so heterogeneous. The fact that cancers are so heterogeneous (genetically, epigenetically, metabolically etc.) means that there will likely not be a cure for it as resistance can evolve.

 

[chrisc]

Just signed up for a DNA analysis which will determine which illnesses I am pre-disposed to. Have had no history or cancer or heart disease in the family, except for uncle who smoked himself to death

 

[RiaX]

The drug companies would invent a new cancer

Nature does that for us

everytime you treat something something worse takes its place, ALWAYS