Novel CoronaVirus (COVID-19) Updates & Discussion

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The_Librarian

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Found a sub of reddit where they refer to COVID-19 and Ebola Zaïre as Corona-chan and Ebola-chan respectively.

Lots of NSFW imagery too.

Tame one I could find of the two together :

df6707d.png
 

TysonRoux

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Talk of bio-weapons gone wrong.


 

Techne

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For those inclined to think it may be a bioweapon:

Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event

Codon usage analyses can resolve the origin of proteins with deep ancestry with insufficient phylogenetic signal or invented de novo. The recently published bat coronavirus sequence however provides strong phylogenetic information to resolve the origin of the Spike protein as well as the rest of the genome suggesting a uniform ancestry across the genome. We have previously shown that phylogenetic discordance in deep relationships of coronaviruses is common and can be explained either by ancient recombination event or altered evolutionary rates in different lineages, or a combination of both [29]. Our study rejects the hypothesis of emergence as a result of a recent recombination event. Notably, the new coronavirus provides a new lineage for almost half of its genome, with no close genetic relationships to other viruses within the subgenus of sarbecovirus. This genomic part comprises also half of the spike region encoding a multifunctional protein responsible also for virus entry into host cells[30, 31]. The unique genetic features of 2019-nCoV and their potential association with virus characteristics and virulence in humans remain to be elucidated.


Interesting figure 2 from the article:


Figure 2: Neighbor joining distance tree of the BLAST search results of the 2019-nCoV (NC_0455_Wuhan_Hu_1) sequence in the genomic region 10901-22830 of the alignment.

In the text:
A BLAST search of 2019-nCoV middle fragment revealed no considerable similarity with any of the previously characterized corona viruses (figure 2).


Also interesting is that the genomic region 10901-22830 (from figure 2) codes for:
Polymerase
Helicase
Endonuclease
Spike proteins.

The spike proteins bind to Angiotensin-converting enzyme 2 (ACE2) which allows the virus to enter human cells. The other proteins play a role in hijacking the replication machinery of the host cell to make copies of itself.

Some evidence suggests that Asians have increased levels of ACE2 receptors.


 

mister

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Thomas Levy wrote a book many years ago with 1200 references about how megadoses of intravenous sodium ascorbate (vitamin C) will handle most viral infections. But nobody seems to care because it's dirt cheap and can't be patented.

Nice to see them trying this:

China is conducting a clinical trial of 24,000 mg/day of intravenous vitamin C to treat patients with coronavirus and severe respiratory complications.

Link: Coronavirus Patients in China to be Treated with High-Dose Vitamin C

Clinical Trial Link: Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia
 

The_Librarian

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Maybe we can invite a couple of refugees from Wuhan to come and live here until it all blows over? :whistling::whistling::whistling::X3:
 

nightjar

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Xi Jinping sends in the hard men to deal with the Wuhan virus
He fires the local bosses who failed to get to grips with the covid-19 outbreak
When secretive, Leninist parties have bad news to get out of the way, they do not hang about. In the space of a single day, February 13th, China’s ruling Communist Party fired the officials who run the province and city at the heart of the epidemic of covid-19, announced a big jump in the number of recorded virus infections there, and sent in hardliners close to Xi Jinping, the country’s supreme leader, to clean up the mess.
 

Polymathic

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For those inclined to think it may be a bioweapon:

Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event

Codon usage analyses can resolve the origin of proteins with deep ancestry with insufficient phylogenetic signal or invented de novo. The recently published bat coronavirus sequence however provides strong phylogenetic information to resolve the origin of the Spike protein as well as the rest of the genome suggesting a uniform ancestry across the genome. We have previously shown that phylogenetic discordance in deep relationships of coronaviruses is common and can be explained either by ancient recombination event or altered evolutionary rates in different lineages, or a combination of both [29]. Our study rejects the hypothesis of emergence as a result of a recent recombination event. Notably, the new coronavirus provides a new lineage for almost half of its genome, with no close genetic relationships to other viruses within the subgenus of sarbecovirus. This genomic part comprises also half of the spike region encoding a multifunctional protein responsible also for virus entry into host cells[30, 31]. The unique genetic features of 2019-nCoV and their potential association with virus characteristics and virulence in humans remain to be elucidated.


Interesting figure 2 from the article:


Figure 2: Neighbor joining distance tree of the BLAST search results of the 2019-nCoV (NC_0455_Wuhan_Hu_1) sequence in the genomic region 10901-22830 of the alignment.

In the text:
A BLAST search of 2019-nCoV middle fragment revealed no considerable similarity with any of the previously characterized corona viruses (figure 2).


Also interesting is that the genomic region 10901-22830 (from figure 2) codes for:
Polymerase
Helicase
Endonuclease
Spike proteins.

The spike proteins bind to Angiotensin-converting enzyme 2 (ACE2) which allows the virus to enter human cells. The other proteins play a role in hijacking the replication machinery of the host cell to make copies of itself.

Some evidence suggests that Asians have increased levels of ACE2 receptors.


Yeah the sample sized used is way too small to make an general sweeping conclusions but I'm sure 23 And Me is working on a tool to identity these genes in their customers genomes. They should have a large enough database to make a more definitive conclusion
 

Lupus

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Whisky - Scotch
Whiskey - Every where else that is not Scotland. :D
Actually
Whiskey - Ireland and the US
Whisky - Scotland and other whisky producing countries. But Scotland you add a Scotch Whisky or Scotch.
 

chrisc

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Friend on board Westerdam which was denied docking in Yokohama, Taiwan and Bangkok has finally arrived in Sinhoukville, a tiny port in Cambodia

Passengers were greeted by an influx of suited medical people who took samples from about 20 people. However, all tested negative for Coronavirus and they hope to leave the ship today. A problem is that there are limited flights out this city and the infrastructure is poor

To say people on board were shitting themselves is putting it mildly

Press release: https://www.hollandamerica.com/blog/ships/ms-westerdam/statement-regarding-westerdam-in-japan/
 
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