Scientists cure cancer - nobody takes notice

jes

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Scientists cure cancer, but no one takes notice

Researchers at the University of Alberta, in Edmonton, Canada have cured cancer last week, yet there is a little ripple in the news or in TV. It is a simple technique using very basic drug. The method employs dichloroacetate, which is currently used to treat metabolic disorders. So, there is no concern of side effects or about their long term effects.
 

SirFooK'nG

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Something fishy.... the research was published in 2007. I am a cancer patient, and I have never heard of it. Bonus if any of it rings true, but I'm skeptical....
 

TJ99

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I don't buy it. If it sounds too good to be true, it probably is. And this sounds pretty damn good.
 

BTTB

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The date of that article is January 2007
A team led by Dr. Evangelos Michelakis at the University of Alberta in Canada have figured out a new use for a safe, cheap chemical already used in medicine for a host of metabolic disorders. This chemical is Dichloroacetate (DCA), and it turns cancer into an angsty, suicidal teenager… the drug must go through the laborious, sisyphic and prohibitively expensive (~ $800m) process of gaining FDA approval. In the case of a drug that needs to be tested on nearly every single type of cancer the process would run into the multiple billions.

This means that no pharmaceutical company is going to get this drug FDA approved, especially since it also makes some of their less effective patented drugs worthless. As a matter of fact, they’ll probably lobby against it with all their might.

This article is similar to the work done by an oncologist in Rome Italy, Dr. Tullio Simoncini in regards to simple Baking Soda here.

Dichloroacetic acid
Sodium bicarbonate/Baking Soda
 
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Elimentals

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If it does work, 20 bucks says it will be bought, patented and stored in a vault deep under some drug company.

They make way to much money "not" curing it.
 

Surv0

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Yes and Marijuana has proven to break down cancer cells and has been around for waaay longer...

Big Pharma doesnt want us to have cheap effective drugs, this puts their bottom line under fire.... we all know profits > health.
 

Budza

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For the locally bound:

Update January 23, 2007
Investigators at the University of Alberta have recently reported that a drug previously used in humans for the treatment of rare disorders of metabolism is also able to cause tumor regression in a number of human cancers growing in animals. This drug, dichloroacetate (DCA), appears to suppress the growth of cancer cells without affecting normal cells, suggesting that it might not have the dramatic side effects of standard chemotherapies. At this point, the University of Alberta, the Alberta Cancer Board and Capital Health do not condone or advise the use of dichloroacetate (DCA) in human beings for the treatment of cancer since no human beings have gone through clinical trials using DCA to treat cancer. However, the University of Alberta and the Alberta Cancer Board are committed to performing clinical trials in the immediate future in consultation with regulatory agencies such as Health Canada. We believe that because DCA has been used on human beings in Phase 1 and Phase 2 trials of metabolic diseases, the cancer clinical trials timeline for our research will be much shorter than usual.
 

oober

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http://www.dca.med.ualberta.ca/Home/Updates/2010-05-12_Update.cfm

DCA Research Team publishes results of Clinical Trials
May 12, 2010

Print this update

Edmonton, AB - Medical Researchers at the University of Alberta reported today evidence that the orphan generic drug Dichloroacetate (DCA) may hold promise as potential therapy for perhaps the deadliest of all human cancers: a form of brain cancer called glioblastoma. The report is published at the journal Science Translational Medicine, a journal of the American Association of the Advancement of Science; it appears today at the journal's web site http://www.sciencemag.org/

In 2007 the U of A team led by Dr Michelakis, published evidence that DCA reverses cancer growth in non-human models and test tubes. The team showed then that DCA achieves these antitumor effects by altering the metabolism of cancer. By altering the way cancer handles its nutrient fuels, specifically the sugars, DCA was able to take away cancer's most important strength, the resistance to death. Since then, several independent groups across the world have confirmed the Alberta team's findings. In December 2009, the editors of "Science" predicted that cancer metabolism is one of only 5 areas across all scientific disciplines, to "watch for major breakthroughs" in 2010.

The U of A team set out to show that the way that DCA works in actual patients is the same with the way it works in the lab. In addition, researchers wanted to show whether DCA is safe and possibly effective in very sick patients with brain cancer.

By extracting glioblastomas from 49 patients over a period of 2 years and studying them within minutes of removal in the operating room, the team showed that tumors respond to DCA by changing their metabolism. Then, the team treated 5 patients with advanced glioblastoma and secured tumor tissues before and after the DCA therapy. By comparing the two, the team showed that DCA works in these tumors exactly as was predicted by test tube experiments. This is very important because often the results in non-human models tested in the lab do not agree with the results in patients. In addition, the team showed that DCA has anti-cancer effects by altering the metabolism of glioblastoma cancer stem cells, the cells thought responsible for the recurrences of cancer.

In the 5 patients tested, the drug took 3 months to reach blood levels high enough to alter the tumor's metabolism. At those levels, there were no significant adverse effects. However, at some of the higher doses tested, DCA caused nerve malfunction, i.e. numbing of toes and fingers. Importantly, in some patients there was also evidence for clinical benefit, with the tumors either regressing in size or not growing further during the 18 month study.

No conclusions can be made on whether the drug is safe or effective in patients with this form of brain cancer, due to the limited number of patients tested by the study's leads Drs Michelakis and Petruk. Researchers emphasize that use of DCA by patients or physicians, supplied from for-profit sources or without close clinical observation by experienced medical teams in the setting of research trials, is not only inappropriate but may also be dangerous. The U of A results are encouraging and support the need for larger clinical trials with DCA. This work is also one of the first in humans to support the emerging idea that altering the metabolism of tumors is a new direction in the treatment of cancer, Michelakis and Petruk said.

The research team hopes to secure additional funding to continue the ongoing trials with DCA at the University of Alberta. Further studies would include more patients with brain cancer, and test the combination of DCA and standard chemotherapies, eventually including patients from other academic health sciences centres.

One of the intriguing features of this work was that it was funded largely by public donations, including philanthropic foundations and individuals. In addition, it received support by Alberta public institutions, both the University of Alberta and Alberta Health Sciences. The multidisciplinary team that performed this challenging translational research included members of the Departments of Medicine, Diagnostic Imaging and Biomedical Engineering, Oncology and Neurosurgery. Clinicians, scientists, nurses and graduate students worked together for 2 years and express their gratitude to the people of Alberta, philanthropists, the patients and their families.
 
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