w1z4rd
Karmic Sangoma
- Joined
- Jan 17, 2005
- Messages
- 49,747
Aneuploidy is most like a bigger contribution.
http://en.wikipedia.org/wiki/AneuploidyAgents capable of causing aneuploidy are called aneuploidogens. Many mutagenic carcinogens are aneuploidogens.
I see you also get some Non-mutagenic carcinogens.
http://en.wikipedia.org/wiki/Carcinogenesis#Non-mutagenic_carcinogensNon-mutagenic carcinogens
Many mutagens are also carcinogens, but some carcinogens are not mutagens. Examples of carcinogens that are not mutagens include alcohol and estrogen. These are thought to promote cancers through their stimulating effect on the rate of cell mitosis. Faster rates of mitosis increasingly leave fewer opportunities for repair enzymes to repair damaged DNA during DNA replication, increasing the likelihood of a genetic mistake. A mistake made during mitosis can lead to the daughter cells' receiving the wrong number of chromosomes, which leads to aneuploidy and may lead to cancer.