I've been running (again) for about 1 year as part of a triathlon training plan. So here are a few tips:
1. Get good shoes. Go to a place like Running Inn (or equivalent). They test your way of running and provide the best shoes. It will prevent injuries and the evil shinsplits.
2. It is stated, but essential. Eat well. Make sure you eat a banana and/or apple an hour before the run. It is natural sugar and bananas contain minerals to prevent cramps
3. Something I'm not doing, but rather run in the morning. It is to do with sugar levels and the correlation to motivation. Afternoons tend to be more difficult to get motivation to run.
4. Get a partner to run with you. The best motivation is someone else.
5. Don't bother with energy drinks, unless you start running longer than 60 minutes. Water, water, water. And keep yourself hydrated (but not over-hydrated).
6. Stretch. Not the stuff you did in primary school. Get a good guide (lots on the internet).
7. Get into what I call, the "zone". It is the point where you have the correct rhythm and pace, your mind forgets how far you need to go and you just enjoy it. Sounds weird, but it occurs it most sports. I get it especially when I swim (but I suspect it is the lack of oxygen

).
8. Get a heartrate monitor. Overstressing your heart when you are unfit isn't healty. I train according to 60-80% of max heartrate, and only peak for no more than 5% of my run at 80-100% of my max heartrate. It is also great to see when the fitness kicks in, that your heart rate lowers. My average hearte rate is now 12% lower than a year ago.
9. Decide your goal. To give you an idea. It took me 6 weeks to get from 5km to 10km runs (excluding all the cycling and swimming). Be realistic
10. A weird thing, but go and run on Fridays. Why? Friday's tend to be the day when we are the "laziest" So, if you can get yourself exercising (even if it is only for 15-20minutes), it will be a motivator for the next week.
This is my experience. It might differ for you, but so use it or don't use it.