I don't have one specific vacation spot in South Africa but I can say that anywhere in South African nature is good for my soul. Give me a small, unobtrusive cottage in the middle of any South African natural ecosystem and I am in bliss.
Hluhluwe Game Reserve. It's unique with Zulu hunt round houses with modern furnished interior there's swimming pool and nearby caged animals, breakfast, lunch and dinner are amazing with great food on offer. Great surroundings better to vacate in Summer time.