Long non-coding RNAs can encode proteins after all
Journal Reference:
Jenna E. Smith, Juan R. Alvarez-Dominguez, Nicholas Kline, Nathan J. Huynh, Sarah Geisler, Wenqian Hu, Jeff Coller, Kristian E. Baker. Translation of Small Open Reading Frames within Unannotated RNA Transcripts in Saccharomyces cerevisiae. Cell Reports, 2014; DOI: 10.1016/j.celrep.2014.05.023
An extraordinary double discovery has been made by researchers. First, they have identified thousands of novel long non-coding ribonucleic acid transcripts. Second, they have learned that some of them defy conventional wisdom regarding lncRNA transcripts, because they actually do direct the synthesis of proteins in cells.
Journal Reference:
Jenna E. Smith, Juan R. Alvarez-Dominguez, Nicholas Kline, Nathan J. Huynh, Sarah Geisler, Wenqian Hu, Jeff Coller, Kristian E. Baker. Translation of Small Open Reading Frames within Unannotated RNA Transcripts in Saccharomyces cerevisiae. Cell Reports, 2014; DOI: 10.1016/j.celrep.2014.05.023