Yes, yes it is.
This is my list of hints for myself to remember each time:
1. New project
2. Import stl
3. go to part workbench
4. select body -> part -> create shape from mesh -> select sew shape -> ok
5. hide initial body
6. select body -> part -> create copy -> refine shape
7. hide previous body
8. part -> convert to solid
9. go to part design, create new body icon on toolbar
10. click basefeature
11. select the face
12. create sketch
13. then pad and extrude and sketch etc
I do recommend this below video, because it shows you it is quite different way of working with STLs vs building something from scratch.
Full video: