I've used Tailwind.
It has it's place, some people swear by it and I get the hype, but it's not for me. I've tried it multiple times, but I get kinda annoyed by the prebuilds before you can start using it for most part.
And If I'm gonna be dealing with pre defined classes, I'd rather use a css framework where the components have already been designed for us, eg Bulma or Bootstrap. At least, you can ship super quickly then with little guess work.
Lately I've been having a lot of fun designing on Figma and then writing CSS from scratch (which is new to me) on my React Apps with Styled Components.
I'm a terrible designer, having fun and learning one step at a time.