Normal hard drives dont spend all of there lives writing so they are not designed for constant read write.
I disagree:
Wikipedia: Hard disk drive said:
A 2007 study published by Google suggested very little correlation between failure rates and either high temperature or activity level
Furthermore the act of reading and writing data does not cause wear. Wear is caused by the movement of the load/unloading of the heads (doesn't occur during reading/writing). Read/writing consists of the head moving into place and the magnetic polarity being read or changed, neither of which wears out a disk drive. The wear on a disk is caused by the moving parts wearing out. The amount of wear before failure is governed by the mean time before failure (MTBF), more from wikipedia:
Wikipedia: Hard disk drive said:
The mean time between failures (MTBF) of SATA drives is usually about 600,000 hours (some drives such as Western Digital Raptor have rated 1.4 million hours MTBF),[70] while SCSI drives are rated for upwards of 1.5 million hours.[citation needed] However, independent research indicates that MTBF is not a reliable estimate of a drive's longevity.[71] MTBF is conducted in laboratory environments in test chambers and is an important metric to determine the quality of a disk drive before it enters high volume production.
Google has completed an large study on the subject matter, and I believe that their research concludes that many of these assumptions and many of the claims by manufacturers are fallacies.
For example: RAID edition drives come with certain settings changed. When a hard-drive usually encounters a sector it cannot read, it will attempt to recover for up to a minute. On a RAID edition drive this recovery time will be set very low so that the drive is not dumped from the array as having become unresponsive. Furthermore those drives also come with longer warranties or feature extra SATA commands (eg. NCQ). For that you pay a hefty price.
Furthermore the belief that a HD must run cool is false:
Wikipedia: Hard disk drive said:
A common misconception is that a colder hard drive will last longer than a hotter hard drive. The Google study seems to imply the reverse—"lower temperatures are associated with higher failure rates". Hard drives with S.M.A.R.T.-reported average temperatures below 27 °C (80.6 °F) had higher failure rates than hard drives with the highest reported average temperature of 50 °C (122 °F), failure rates at least twice as high as the optimum S.M.A.R.T.-reported temperature range of 36 °C (96.8 °F) to 47 °C (116.6 °F).[68]
My advice, buy the cheapest drive that will suit your needs AND is supported by the manufacturer. While keeping that in mind I'll share some of my own personal experience with you:
I run a NAS and I've setup a few others. If you are planning on running 6 drives in a single unit, then buy low power drives! I currently run a 6x2TB drive NAS with low power 3.5" drives and the heat output is quite high. At idle these hard-drives sit at 40 degrees, under load the go up to 46. That is with the case open and a fan blowing on them.
Also, some of the newer large capacity drives feature something called advanced format, where the sector size has changed. Trust me on this, DO NOT buy an advanced format drive UNLESS the manufacturer EXPLICITLY says otherwise. It's a long story but those drives can have SIGNIFICANTLY reduced performance if not supported (write speeds on a WD Advanced format with unsupported device is 4mb/s VS the normal 80mb/s if supported. Not sure if I should point out that 4mb/s is unacceptable).
Lastly, BEWARE of Seagate. Even some of the newer models feature firmware bugs, not just the 11 series. For example the new Seagate LP (low power) drives also have a firmware bug. Personally I think for low power Western Digital Green Power is the best. Just be careful because the WD EARS drives (eg. WD20EARS is a 2 terabyte drive with 64mb cache) IS AN ADVANCED FORMAT DRIVE! Rather get the WD20EADS instead, or etc.
Some of the new Samsungs sold by Esquire are ALSO advanced format (4kb sector size instead of 512k sector size).