Thanks for the advice, why do you say "fewer but larger"? Surely a bigger meal has a larger chance to spike your sugar (obviously if it has carbs/sugars).
Because depending on the spacing of the meals, your body will spend more time in a low insulin state.
Please start reading up on intermittent fasting. I especially recommend the blogs MarksDailyApple.com and intensivedietarymanagement.com (written by Dr Jason Fung, a Canadian kidney specialist).
Short version - every time you eat something containing either protein or carbs (ie everything), your body secretes insulin. Insulin is an essential hormone responsible for moving nutrients into your tissues. Insulin itself is healthy and absolutely essential to life - what is not healthy is insulin resistance. Insulin resistance means your cells are resistant to insulin, so your body has to produce more of it for it to have an effect. It is an essential component of diabetes.
How does insulin resistance develop? If you have elevated insulin levels for too long, you will become insulin resistant. In other words, eating small meals all day long is bad for you because your body needs to secrete insulin to deal with it. This will cause insulin resistance, or, if you already have it, make it worse.
The best way to lower insulin resistance is fasting. The length of the fast is up to you - I just skip breakfast every day, and have my first meal normally around 12PM. I used to have my first meal at 4:30PM for a couple of months.
The relationship between sugar and insulin is that insulin is released to bring blood sugar levels down, because too much glucose in your blood is actually toxic. This is why high sugar foods cause a large insulin response. Protein however also causes an insulin response, so be aware of that.
Yes, the size of the blood sugar/insulin spike does matter, but it isn't the only thing that matters. To get the best out of your diet, reduce the frequency of your meals and increase the amount of animal protein and veggies that you eat