This depends on a lot of things, however with certain things you just won't notice this at all. Lets say you use spd/if, optical or coax, since its a digital signal, and the DACs on the soundcard are bypassed in this mode, there will be absolutely zero difference sound wise, zero difference in quality, since the AMP will be doing the decoding from digital to analog.
If you however use analog cables to pass the sound from the soundcard to the amp, things change completely, the DACs on the soundcard become important for quality of the sound ect.
So it really depends on how you will be using it, my guess is you will be using spd/if, thus the only thing you should be interested in is whether the card you buy can do that or not, and generally speaking the PC doesn't cause interference when the sound is still digital.