Proton Pump Inhibitor (PPI) Medication Side Effects

Beginning last year I had this sore throat that wouldnt go away. Thought covid and what not for a while. GP gave me all kinds of things to try.

Eventually I want to an ENT he said Ive got some reflux causing the sore throat. So I went to a gastro did a scope and he told me I have a hiatus hernia. One of the issues I have is this shortness of breath feeling which is caused by the reflux (figured this out again after going to emergency rooms etc thinking im having some cardiac episode)

Anyway doc put me on nexmazol 40mg this worked for a while, but then this stopped working for me. He moved me to pariet 20mg that seems to do the job.

Ive been taking it now for 12months +- was also worried about long term side affects, seems to be little data about it.

Doc said op has a good 60% chance that your issues will come back within 5 years so its not worth doing
 
mono2 said:
Doc said op has a good 60% chance that your issues will come back within 5 years so its not worth doing
Click to expand...

The surgeon who did my op said it should last me for the rest of my life after my last scope (I'm ashamed to say that I'm a hypochondriac). And when asked he clarified that the op should last anyone for the rest of their lives. I'm now 4 years in.

The crude long-term failure rate was 24.5% (34 of 139 patients): 6 patients (4.3%) underwent reoperation for symptomatic and objective recurrence caused by defective plication, 16 (11.5%) had heartburn, regurgitation, dysphagia and PPI medication on a daily/weekly basis, 11 patients (7.9%) not using PPI medication reported frequent/daily symptoms, and 1 was asymptomatic while on medication (Figure (Figure1B1B and C). The cumulative 5-year failure rate was 12.3% (95%CI: 7.8%-36.0%) and the 10-year failure rate 27.1 %
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Quality of life following laparoscopic Nissen fundoplication: Assessing short-term and long-term outcomes - PMC

AIM: To investigate the quality of life following laparoscopic Nissen fundoplication by assessing short-term and long-term outcomes. METHODS: From 1992 to 2005, 249 patients underwent laparoscopic Nissen fundoplication. Short-term outcome data ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

I also believe that the better the surgeon, the better the long term outcomes will be.

Edit:
That said, if you have a hiatal hernia, you most likely have a weak diaphragm, meaning there is a chance the whole thing might push through again. So yes, if go on lifting heavy stuff, you could cause it again.
 
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Roger Banana said:
Been on PPI (40mg nexiam a day) for 18 years, I would have cancer without it so I'm not stopping any time soon. Go for gastroscopies every few years to check all is ok, and do blood tests once a year to check kidney function etc. All good for me.
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Also was prescribed Nexium but 20mg , been on PPI for 2 years and it's a life charger.

Brawler said:
I also have a small hernia and gastritis. Surgeon and Doctors recommended I take meds rather than surgery as surgery doesn't have a high success rate and terrible side effects. They only really recommend surgery if the hernia is huge.

Trustan 20mg seems to do the trick for me (been on it for maybe 6 months). At the last consult I specifically asked the GP about side affects and he said only really super long term and its inconclusive. He did recommend I try to cut back to every 2nd day so there must be something to it.

The problem is that Trustan works quite well and now I am not eating and drinking well (for a person with GERD) and living my best life. If I am to cut back on Trustan I am going to need to put in the effort.

On another note the gastritis started days after taking the j&j covid vaccine. Another forumite also mentioned this. #justsaying.
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Trustan is the generic of Nexium , I take Trustan instead, way cheaper.
 
L-Dog said:
Hey Guys

So I have small hernia in my stomach that causes heart burn. Doctor said operational is option but not necessary and prescribed topzole for my heart burn (This was a good 5 years ago). I recent went for a general check up and the new doctor warned me about side effects and that PPI medication gives a higher chance of Alzheimers. Game plan is to slowly move of Topzole and the drink Gaviscon daily (doctor says its safer although not as effective) Curious if anyone else is on PPI's and what their doctor said ?

Thanks
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how tall are you and how much do you weigh?
 
Barbarian Conan said:
The surgeon who did my op said it should last me for the rest of my life after my last scope (I'm ashamed to say that I'm a hypochondriac). And when asked he clarified that the op should last anyone for the rest of their lives. I'm now 4 years in.



Quality of life following laparoscopic Nissen fundoplication: Assessing short-term and long-term outcomes - PMC

AIM: To investigate the quality of life following laparoscopic Nissen fundoplication by assessing short-term and long-term outcomes. METHODS: From 1992 to 2005, 249 patients underwent laparoscopic Nissen fundoplication. Short-term outcome data ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

I also believe that the better the surgeon, the better the long term outcomes will be.

Edit:
That said, if you have a hiatal hernia, you most likely have a weak diaphragm, meaning there is a chance the whole thing might push through again. So yes, if go on lifting heavy stuff, you could cause it again.
Click to expand...
You had a hiatal hernia?
 
If you have medical aid, just get a Nissen Fundoplication and get done with it. I was on Nexium for a good chunk of my life. It is only going to get worse, even if you are living a healthier lifestyle it will only postpone the inevitable.

My opinion, better get a doctor's opinion.
 
Fulcrum29 said:
If you have medical aid, just get a Nissen Fundoplication and get done with it. I was on Nexium for a good chunk of my life. It is only going to get worse, even if you are living a healthier lifestyle it will only postpone the inevitable.

My opinion, better get a doctor's opinion.
Click to expand...
How long ago did you do this? Happy with the results ?
 
Fulcrum29 said:
If you have medical aid, just get a Nissen Fundoplication and get done with it. I was on Nexium for a good chunk of my life. It is only going to get worse, even if you are living a healthier lifestyle it will only postpone the inevitable.

My opinion, better get a doctor's opinion.
Click to expand...
It's a pity the LINX procedure isn't available locally. Seems a simpler and easier option to do the same thing.
 
mono2 said:
Who is your surgeon ? Mind sharing details ?
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Prof Heine van der Walt at Unitas hospital in Centurion.
As I said earlier, he pretty much does hiatal hernia repairs and gastric bypasses. When I had my op there were also people who drove up from Jefereys bay for the op. For my first op die waiting list before my first appointment was 11 months. He does the scope in his rooms (some medical aids don't require excess when it is in Drs rooms) with the first appointment.
 
Barbarian Conan said:
Prof Heine van der Walt at Unitas hospital in Centurion.
As I said earlier, he pretty much does hiatal hernia repairs and gastric bypasses. When I had my op there were also people who drove up from Jefereys bay for the op. For my first op die waiting list before my first appointment was 11 months. He does the scope in his rooms (some medical aids don't require excess when it is in Drs rooms) with the first appointment.
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Awesome, im in Centurion thank you
 
One thing to note with PPIs is that they inhibit the absorbtion of Vit B. This leaves me with slight tremors in my hands when I take PPIs for a long period of time.
Discussed it with my GP (and he confirmed my research of why my hands were shaking) and he prescribed me Neurobion Forte which I took at night, so that my body had time to absorb it before the morning when I took the PPI. I also increased my intake of foods rich in Vit B.
 
There is a new PPI in the SA market called dexilant 30mg and 60mg ,now considered to be the strongest one .
 
killerbyte said:
One thing to note with PPIs is that they inhibit the absorbtion of Vit B. This leaves me with slight tremors in my hands when I take PPIs for a long period of time.
Discussed it with my GP (and he confirmed my research of why my hands were shaking) and he prescribed me Neurobion Forte which I took at night, so that my body had time to absorb it before the morning when I took the PPI. I also increased my intake of foods rich in Vit B.
Click to expand...
Thanks for the info. Tremors gone?
 
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