Here is a nice little top for speeding up your Mail.app
1. Close Mail.app
2. Open Terminal
3. Execute "cd ~/Library/Mail"
4. Execute "sqlite3 ./Envelope\ Index"
5. A little interactive sqlite app will open
6. Type "vacuum subjects;"
7. Once the command finishes execution, press Crtl + D to close sqlite
8. Close terminal
9. Now run mail and you should see a noticable difference
1. Close Mail.app
2. Open Terminal
3. Execute "cd ~/Library/Mail"
4. Execute "sqlite3 ./Envelope\ Index"
5. A little interactive sqlite app will open
6. Type "vacuum subjects;"
7. Once the command finishes execution, press Crtl + D to close sqlite
8. Close terminal
9. Now run mail and you should see a noticable difference