Guys guys guys... I have the P280, and it is not as quiet as they state! Don't get the P280, it's ridiculously heavy, not quiet, and the cooling isn't that great. Although there is a lot of space for fans. I had to install on my HHD cage to blow directly on my GPU. It has a lot of features inside, but overall, it's not the sexy beast you'd want it to be.
I'm going to take NomNom's build and tweak it a bit.
Case: R2,284.00 (you can save on the case, but it is the best case in the world IMO and if you take it now, you'll never need another one)
Cooler Master Trooper, Full Tower, Black, Windowed side panel
PSU: R1,598.00 (we can go a bit less if you decide not to go CrossFire later)
SeaSonic X 750w Gold
Motherboard: R2,399.00 (the price jumped overnight to R2,414.00)
ASRock Z87 Extreme6
Also look at: R2,355.00
GIGABYTE GA-Z87X-UD3H
CPU: R3,999.00
Intel Core i7-4770K
If you want 8GB of RAM and get another 8GB later, you'll save enough to get a watercooler.
RAM: R2,106.00
G.Skill F3-2133C10Q-16GAB
Also look at: R2,045
G.Skill F3-2133C10D-16GXM
GPU: R3,799.00
PowerColor AXR9 280X 3GBD5-DHE Radeon R9 280X 384bit PCI Express 3.0 Desktop Graphics Card
Also look at:
Sapphire R9 280X Toxic Edition (A good alternative to look at, because it's the best 280X out there and looks amazeballs, I'd take the PowerColor because of it's cheapness!)
SSD: R2,459.00 (Cheaper at Rebeltech, but sold out)
Samsung MZ-7TE250 840 Evo Series 250GB 2.5" TLC SATA III Solid State Drive
HDD: R1,099.00 x 2 = R2,198.00
Seagate ST2000DM001 2TB 7200RPM SATA III 64MB Cache 3.5" Internal Hard Drive
Opitcal Drive: R1,005.00
LG BH16NS40, 16x Blu-Ray writer, Black
CPU Cooler: Just to keep it cooler and quiet...
Zalman LQ310 R888
Thermaltake Water 3.0 Performer R844
Total: My alternatives (except for GPU) + Zalman cooler + Shipping = R22819
There is a lot of places where we can cut costs, but this is as epic as it will get! All the other nice looking goodies will add to the cost quickly. That you can buy afterwards.