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Hi Johan
Both the Sigma 50-500 (Bigma) and the 150-500 are good value lenses. They are however both relatively heavy. Sigma also make a 170-500 model which is not generally as highly recommended. I previously owned the 50-500 (non OS) which I sold when I bought my current Canon 100-400 (which is not weather sealed by the way). In my opinion I find the Canon 100-400 overall a faster and lighter lens and I obtain a higher percentage of good results. That said I do still sometimes miss the versatility of the 50-500 and when I got it right the IQ was great as well.
The Canon EF 100-400mm f/4.5-5.6 L IS USM Lens is a partially weather sealed lens. A lens mount gasket is not present, but the switches, focusing ring and zoom ring have moderate dust and moisture resistance. A front filter should be used for sealing purposes.