Agonizing and debilitating attacks of gout, an inflammatory disease affecting the joints, could soon be consigned to history, thanks to a non-invasive test that can detect the disease before the first painful symptoms strike. Keiji Yashio and Yasuyoshi Watanabe at the RIKEN Center for Molecular Imaging Science at Kobe and their colleagues developed the test that, as well as being useful for diagnosis, could finally reveal exactly what triggers bouts of the disease.
Gout attacks can occur when uric acid levels rise to abnormally high levels in the blood, and then begin to accumulate and crystallize in the lubricating, or synovial, fluid within joints. Patients tend to experience the disease as a series of attacks, and currently there is no way to detect when an attack is about to begin.