How Psilocybin Improves Your Brain

crackersa said:
Speak to a doctor
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Even if a medical doctor of any credibility had enough information on this particular combination of chemicals to have an informed opinion, he/she couldn't ethically advise me to go ahead, since it's an illegal substance in the US. Hence, why I'm on a freakin' message board.

Also, I *did* privately consult a well-researched and currently practicing medical doctor and microbiologist who I advised that I consult Erowid. Because of it's Class IV designation, it's not like asking your doctor if you can take a xanax with a decongestant.
 
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OhYouKnow said:
Even if a medical doctor of any credibility had enough information on this particular combination of chemicals to have an informed opinion, he/she couldn't ethically advise me to go ahead, since it's an illegal substance in the US. Hence, why I'm on a freakin' message board.

Also, I *did* privately consult a well-researched and currently practicing medical doctor and microbiologist who I advised that I consult Erowid. Because of it's Class IV designation, it's not like asking your doctor if you can take a xanax with a decongestant.
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Erowid would be a good start, I've gotten most of my dosing info for various substances from there.

Just go balls to the wall and do McKenna's heroic dose in a complete dark and quiet room ;)
 
OhYouKnow said:
I want to microdose mushrooms (no idea/preference what variety) for psychological "clarity" on some personal matters and issues.
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For that I'd just take a regular dose once-off.
 
OhYouKnow said:
So what did we decide?

I use 6mg Emsam daily. It's prescribed to me by a doctor for medical purposes (abates my CFS/FM symptoms 85%). It's a selective irreversible MAO-B inhibitor.

I also take 3mg of naltrexone (low dose naltrexone, LDN) for the same condition.

I want to microdose mushrooms (no idea/preference what variety) for psychological "clarity" on some personal matters and issues. I'm looking for info about safety concerns of microdosing while taking 6mg transdermal Emsam.

What do I need to look out for? Do I need a washout period?
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Physically it should be safe. In all likelihood it will severely blunt the effect of the microdose. At 6mg a day transdermally selegiline is likely going to loose its MAOI-B selectivity over time and increase your production of serotonin.

The thing you have to look out for is Phenethylamines eg. Mescaline in Cacti or the 2C class of chemicals. Both anecdotally and from what we know in scientific literature a MAOI-B is going to potentiate it a lot.(There are a few nay sayers saying SSAO is responsible for breaking down these Phenethylamines and not MAO, but I'll rather not risk it)
 
It is still rather amusing to see how they sell these stuff on the corner in stores in the Netherlands. Although the mushroom is now illegal, but the root (truffles) is not, but it still contains the psilocybin, so not quite sure why there's this distinction. But i guess if you need a fix, Amsterdam got it all ;-)
 
OhYouKnow said:
So what did we decide?

I use 6mg Emsam daily. It's prescribed to me by a doctor for medical purposes (abates my CFS/FM symptoms 85%). It's a selective irreversible MAO-B inhibitor.

I also take 3mg of naltrexone (low dose naltrexone, LDN) for the same condition.

I want to microdose mushrooms (no idea/preference what variety) for psychological "clarity" on some personal matters and issues. I'm looking for info about safety concerns of microdosing while taking 6mg transdermal Emsam.

What do I need to look out for? Do I need a washout period?
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Personally i think mixing ssri's with shrooms is pointless.
Its a unclear road. Some have no issues, and some people have severe issues.

But most of the time is will just do nothing to you while on ssri's
 
crocopede said:
Personally i think mixing ssri's with shrooms is pointless.
Its a unclear road. Some have no issues, and some people have severe issues.

But most of the time is will just do nothing to you while on ssri's
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SSRIs made me think of suicide more . Shrooms are amazing ! Had 300g last night . Mix it with some lemon juice
 
Why do people mix their shrooms with stuff. They are delicious as is.
Unless you dont like the taste of mushrooms i guess.

300 grams of mushrooms will send you to heaven where you will become god and destroy all that exists and afterwards realize what you just did and then demote yourself back to human status right after you recreated everything from scratch and sat back while observing time unfold and dinosaurs walked the earth etc.

:crylaugh:
 
crocopede said:
Why do people mix their shrooms with stuff. They are delicious as is.
Unless you dont like the taste of mushrooms i guess.

300 grams of mushrooms will send you to heaven where you will become god and destroy all that exists and afterwards realize what you just did and then demote yourself back to human status right after you recreated everything from scratch and sat back while observing time unfold and dinosaurs walked the earth etc.

:crylaugh:
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Apparently the lemon helps to break it down :crylaugh:
 
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