Opiate Withdrawal (Tramadol)

scud said:
Shaun108
Going cold turkey on ssri's can be really hectic to some. Always better to taper down over a few weeks/months. The quick change can be really dramatic.
Out of interest, did ssri's give you wrestles legs, or have you had that before?
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I never had restless legs before. It was like there were ants crawling inside my legs and a terrible feeling of discomfort unless I move my legs.
 
Find a new doctor if yours didn't advise you to start tapering the dose in the last week and a half or so.
 
Shaun108 said:
What can I do to make the Opiate and SSRI withdrawal a little easier? (The doc did tell me that I will experience a few days discomfort after my dosage regimen is done.)
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I would suggest a liver tonic, vitamins and/or food stuff relevant to detoxing the liver.

Under Pharmacokinetics in the Tramadol link http://en.wikipedia.org/wiki/Tramadol

Tramadol undergoes hepatic metabolism via the cytochrome P450 isozyme CYP2B6, CYP2D6 and CYP3A4
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,

Hepatic = Liver

CYP3A4
mainly found in the liver and in the intestine. Its purpose is to oxidize small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body.
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http://en.wikipedia.org/wiki/CYP3A4

CYP2D6
CYP2D6 is primarily expressed in the liver.
In particular, CYP2D6 is responsible for the metabolism and elimination of approximately 25% of clinically used drugs
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http://en.wikipedia.org/wiki/CYP2D6

Tramadol is an opioid analgesic used for the therapy of mild-to-moderate pain. Tramadol overdose can cause acute liver failure.
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http://livertox.nlm.nih.gov/Tramadol.htm

Clearly Tramadol has a negative effect on the Liver in large doses, so therefore it is safe to assume in smaller doses or in cases of withdrawal/end of treatment it is best to detox the Liver ASAP.
 
not much you can do with tramadol withdrawals. Tough it out
 
I was on a **** load of tramadol for a leg that is completely fubar.

Eventually I started realising that I needed the tramadol to just be alive, not to even remove the pain.


I decided to quit cold turkey, the withdrawal symptoms were ****ing awful.


Don't worry - after a month or so you will start feeling like a human again.
 
Clearly Tramadol has a negative effect on the Liver in large doses, so therefore it is safe to assume in smaller doses or in cases of withdrawal/end of treatment it is best to detox the Liver ASAP.
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this wont help with withdrawals and the liver will normalise over time maybe 2 to 3 days. No need to waste money on 'detox'
 
Huh? Who knew. I was on tramadol - really tasty stuff. The constant falling asleep state is blissful as ****. Codeine in my experience really has nothing on it - even at similar dosages.

But now I wonder if it's the reason I've been struggling to sleep without waking up early in the morning, and whether going off of it contributed to my anxiety.

If I had to go onto an SSRI, I'd definitely gun for something similar as experiences seem to differ heavily from drug to drug between people when it comes to antidepressants.
 
Garson007 said:
Huh? Who knew. I was on tramadol - really tasty stuff. The constant falling asleep state is blissful as ****. Codeine in my experience really has nothing on it - even at similar dosages.

But now I wonder if it's the reason I've been struggling to sleep without waking up early in the morning, and whether going off of it contributed to my anxiety.

If I had to go onto an SSRI, I'd definitely gun for something similar as experiences seem to differ heavily from drug to drug between people when it comes to antidepressants.
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The experience of Tramadol is not remotely similar to an SSRI. Tramadol, is awesome, while SSRIs are awful.

I say awful, in the context of (possibly incidental) recreational use, for which Tramadol has high (but dangerous) value.
 
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