Roaccutane/Oratane

[killadoob]

What I mean is that oily skin ages better than dry skin. If isotretinoin permanently reduces oil production then your skin may age faster (more wrinkles).

I think it's really hard to make a claim regarding the aging, i don't think you can really study a group of people for 10-15 years who are so different. Some are in the sun a lot, use sunbeds, smoke, drink, eat poorly etc. So that will always be possible i guess.

 

[Swa]

What I mean is that oily skin ages better than dry skin. If isotretinoin permanently reduces oil production then your skin may age faster (more wrinkles).

Quite possibly. It's also made my skin flaky. That and the other side effects I seriously wouldn't have used it if I knew.

Correct. Woman needs to sign a document promising they are not pregnent...nor will they become pregnant while on treatment. Not sure if this is still the case. Birth defects are basically guaranteed and are severe on this drug.

That is a requirement of the FDA. I don't think we have any such program.

I have also heard of birth defects after taking it. The very same birth defects it causes. I really think this drug should be reevaluated and a proper study done on its effects.

 

[reactor_sa]

This **** cleared my skin up back in grade 7,when I started working I had to go on it again. Biggest mistake ever. You can get away with it once, but the second time will almost definitely have long term side effects. This **** messed up my joints, dried them out long term. I still get acne sometimes. Try cutting sugar from your diet before taking this ****. Milk sugar included.

 

[falcon786]

This **** cleared my skin up back in grade 7,when I started working I had to go on it again. Biggest mistake ever. You can get away with it once, but the second time will almost definitely have long term side effects. This **** messed up my joints, dried them out long term. I still get acne sometimes. Try cutting sugar from your diet before taking this ****. Milk sugar included.

Seems like it has had horrible side effects for many of us here!

 

[killadoob]

Seems like it has had horrible side effects for many of us here!

For many though it was a life saver. You must just know what you are in for. it may have side effects but it cleared my chronic acne. Some people though go overboard and take the stuff when they have mild acne.

This medication is for persistent bad acne.

 

[RiaX]

Quite possibly. It's also made my skin flaky. That and the other side effects I seriously wouldn't have used it if I knew.


That is a requirement of the FDA. I don't think we have any such program.

I have also heard of birth defects after taking it. The very same birth defects it causes. I really think this drug should be reevaluated and a proper study done on its effects.

exactly why you shouldnt comment on medical aspects.

1) we have the programme in place. The doctors make you sign a document and take a pregnancy test.

2) It has a huge red textbox that states "teratogenic do not use if pregnant"

3) It doesnt have to be re-evaluated for teratogencity because its meant for teenagers who have acne problems

4) there are enough studies on it and its clinical use - if you actually looked you will find it but once again you are stating things without even reading up and pretending to be an expert

why dont you recommend vitD again ...

 

[Kornhub]

Dermatologists are very strict about the pregnancy part. Just read the brochures at the dermatologist and it has fat signs about pregnancy and birth defects.

 

[killadoob]

Dermatologists are very strict about the pregnancy part. Just read the brochures at the dermatologist and it has fat signs about pregnancy and birth defects.

Trouble is doctors are giving the drug out. I didn't need a dermatologist to know it was either this drug or stay hidden for many years.

 

[Humberto]

This past weekend, because it was Easter, I binge-ate Easter eggs. On Monday I had an acne breakout.

 

[Swa]

For many though it was a life saver. You must just know what you are in for. it may have side effects but it cleared my chronic acne. Some people though go overboard and take the stuff when they have mild acne.

This medication is for persistent bad acne.

Some of us were not told about the side effects though and that they are permanent and more common than claimed. The derm also made it seem like it is a LOT safer than it really is.

exactly why you shouldnt comment on medical aspects.

1) we have the programme in place. The doctors make you sign a document and take a pregnancy test.

2) It has a huge red textbox that states "teratogenic do not use if pregnant"

3) It doesnt have to be re-evaluated for teratogencity because its meant for teenagers who have acne problems

4) there are enough studies on it and its clinical use - if you actually looked you will find it but once again you are stating things without even reading up and pretending to be an expert

why dont you recommend vitD again ...

And this is why YOU should not comment on any post.
1) I said I'm not sure if there's a similar program. We can't have the same program as the iPLEDGE is a U.S. FDA requirement. It's a LOT more than just signing a document and taking a pregnancy test. That's the SMART program which was discontinued as it was a complete failure.
3) It needs to be reevaluated for safety and side effects. Safety during pregnancy does not need to be "reevaluated" because we already know it's not safe.
4) Yes there are a lot of studies showing its effects even when side effects are not apparent. Again you are making assumptions about my knowledge while being clueless yourself. What's needed is a formal regulatory review of all the studies.

Vitamin D? Why should I? There are no studies I know of that link it to improving acne. But since isotret shrinks or destroys sebaceous glands it may be wise to take it during and after treatment FOR THE REST OF YOUR LIFE. Again your pharmaceuticals throwing a spanner into the way nature works.

 

[killadoob]

Well why do you need to be told the side effects, there is a pretty long list in the packaging for you to read? Is it common practice for you to ignore the warnings in the packaging?

 

[RiaX]

because swa is dof like that

it cant even count 1 3 4

and there are enough review papers on isotret .... once again you showing you know f**k all.

 

[Kornhub]

Trouble is doctors are giving the drug out. I didn't need a dermatologist to know it was either this drug or stay hidden for many years.

I didn't know doctors gave it out? Did they do a blood test on you guys before you took it?

 

[reactor_sa]

This past weekend, because it was Easter, I binge-ate Easter eggs. On Monday I had an acne breakout.

Switch to dark, like 80% cocoa. Less sugar, less milk.

 

[killadoob]

I didn't know doctors gave it out? Did they do a blood test on you guys before you took it?

Nope, i was like 17 hey. When you have boil acne back, chest and face a doctor will give you a script. Dermatologists will try suck you into seeing them and spending lots of money to clear your face. I didn't need a blood test. I was young and healthy.

3 months and my acne was practically gone apart from the scarring but that adds character so i don't mind .

 

[Swa]

Well why do you need to be told the side effects, there is a pretty long list in the packaging for you to read? Is it common practice for you to ignore the warnings in the packaging?

That's just it. The packaging doesn't list all the side effects and it doesn't tell you they are permanent. On top of that the doctor makes it seem extremely safe.

because swa is dof like that

it cant even count 1 3 4

and there are enough review papers on isotret .... once again you showing you know f**k all.

And you're not reading or grasping what's said as usual.

I didn't know doctors gave it out? Did they do a blood test on you guys before you took it?

I don't see why they should when dermatologists don't even do that.

 

[RiaX]

That's just it. The packaging doesn't list all the side effects and it doesn't tell you they are permanent.

it does. It tells you everything that is known. Where you get this nonsense from ?

And you're not reading or grasping what's said as usual.

Because its rubbish

I don't see why they should when dermatologists don't even do that.

they do ? I managed a government skin clinic where dermatologists are trained. Every single patient was monitored.

Once again swa you just lie and talk nonsense. Rare events that happen one in a 100 000s of treatments does not make it an acceptable norm

SO STFU when you have no experience

 

[Swa]

it does. It tells you everything that is known. Where you get this nonsense from ?

From the package insert! How much clearer must I make this so every idiot can understand?

they do ? I managed a government skin clinic where dermatologists are trained. Every single patient was monitored.

Once again swa you just lie and talk nonsense. Rare events that happen one in a 100 000s of treatments does not make it an acceptable norm

SO STFU when you have no experience

So you are effectively using ad hominem attacks again. I would have noticed if blood was ever drawn you fool. I told you before if you can't engage in debate then just **** off.

 

[RiaX]

From the package insert! How much clearer must I make this so every idiot can understand?

Once again you puny mind cant see reality. ok swa please explain the following:

1) How they found this drug

2) how they quantified its activity

3) How they made it selective to sebacious glands only

4) How they determined its chemical structure

5) How they refined it

See an innovative pharmaceutical company will pull the plug on its R&D of a drug once the project is complete. Its expensive and the human resource can be better used on the next project. The universities world wide handle the minor details (this is why they fund the schools of pharamacology and medical schools worldwide). So you have a grand misconception on what they mean by "Not fully understood" its not "we dont know a thing about it"

You really think they going to publish their sensitive information ? or waste their money on legalities.

so naive

So you are effectively using ad hominem attacks again

ah its back ... Swa do you even know what it means ? define it and point it out for me. Clinical experience is not ad hominem or is stating the fact that you are lying and talking nonsense and extrapolating your experience as a norm. Poor intellect very poor

I would have noticed if blood was ever drawn you fool.

Well you believe in homeopathy and alternate medicine, yet you claim to use antidepressants and isotret and basically every single drug anybody has a question about. I can input on all of them because im a drug specialist its my job.... Also just because you had a dumb doctor that doesnt mean the entire world follows that procedure. Knowing you you probably moaned at the cost or had an know it all attitude so your Dr was like "F**k this oke leave him" .... we do that to people who think they know more medicine than people who are trained in medicine.

most medical officers wont waste their time debating with know it alls. They will take your money for consult and throw you out and thats your own damn fault.

I told you before if you can't engage in debate

Thats you not me. BTW i have no intention of debating with you. You a nutcase that advocates fraudulent treatments. A mere conartist, thief, liar or moron (you pick which one you are). Im only bothering to post after your nonsense because some poor soul out there may succumb to your nonsense and it will affect them seriously.

People should never seek medical advice over the internet, but today's times are tough its not cheap or feasible to run to your Dr everytime something small comes or if you have a question you forgot to ask your Dr/pharmacist. So one cannot blame them for looking for advice easily and cheaply. Unfortunately vultures like you exist. Though I wont let you get away with your cons

 

[RiaX]

if you must know this is how any retinoid derivative works

Retinoids (natural and synthetic derivatives of vitamin A) are known to affect the growth and differentiation of any types of cells. Retinoids regulate gene transcription by binding to and activating retinoic acid receptors (RAR-a,-b,and-c) and 9-cis-retinoic acid(9cRA) receptors (RXR-a,-b, and -c). All-trans-retinoicacid, atRA, is generally thought to exert most biological actions of retinoids. Retinol is metabolized to atRA in a tightly controlled two-step oxidative process, starting with the conversion of all-trans-retinol to all-trans-retinaldehyde, followed by the conversion of all-trans-retinaldehyde to atRA (for a review, see [1] or [2] and references therein). Oxidoreductases known as retinol dehydrogenases (RDHs) catalyze the first reaction, which appears to be rate limiting [2] while cytosolic retinaldehyde dehydrogenases are thought to catalyze the second reaction [3,4].

Several isoenzymes belonging to the short chain de-hydrogenase/reductase (SDR) superfamily with various co-factor and substrate preferences have been cloned from mammals. Some of these only recognize all-trans-retinol as substrate [5–8], whereas others may also metabolizecis-retinols (9-, 11-, or 13-cis-retinol) [9–16]. Many of these SDRs also oxidize androgens, primarily the 3a-hydroxysteroids 3a-adiol (5a-androstan-3a,17b-diol) and androsterone (5a-androstan-3a-ol-17-one) into DHT (dihydrotestosterone) and androstanedione (5a-androstan-3,17-dione), respectively [2]. Recently, the first human counterpart to a RDH-like SDR, called RoDH-4, was cloned [17]. RoDH-4, a NADþ-preferring oxidoreductase expressed in the liver, is able to oxidize all-trans-retinol and 13-cis-retinol as well as 3a-adiol and androsterone, thus being the first human micro-somal enzyme capable of metabolizing all-trans-retino to its corresponding aldehyde. nterestingly, the oxidative 3a-HSD activity of RoDH-4 is competitively inhibited by both all-trans-retinol and 13-cis-retinol

More recently, RoDH-4 has also been reported in human epidermis under the name hRDH-E [18]. This is of particular interest since vitamins in the form of all-trans- and 3,4-didehydroretinol are metabolized to reti-noic acids in the skin [19,20], and androgens, such as DHT, are potent stimulators of sebocyte growth and differentiation [21,22]. For years, skin disorders such as acne and psoriasis have been treated with natural (atRA and 13-cis-retinoic acid, 13cRA) or synthetic (e.g., acitretin and adapalene) retinoids either topically or orally

thats just the tip of the iceberg swa ..... there are over 200 000 articles on isotret alone

damn its annoying pasting out of pdf. Im sure you understand all of that LOOOL. Oh and dont make yourself a moron by commenting on the words you understand

I will wait your standard response of

posting link to alternative pseudomedicine
or saying that you cant access it therefore its "fake" .... mind boggling that one would think expensive pharmaceutical information would be freely available LOL. Do you expect the HPCSA to post you a copy of the SAMJ too ? or the SAPC to post you a copy of SAPJ?

I use petrol ! where is my free car magazine ROFL