Roaccutane/Oratane

Riax you really need to chill, pop a couple benzo's.

The drug is basically a very high dose of vitamin A
 
Yeah RiaX you really need to chill,the op's initial question was valid and in my case the side effects were far worse than any doctor or other research i done even on the net pointed out.I think thats basically what swa was also trying to say.The side effects can be worse than current documentation/research suggests.

OP,just be sure to drink tons of water and if you feel anything not exactly perfect go see your doctor rather than leave it to get worse.Oh and as for face cream Clicks used to have one made by yardley called black magic or something along those lines it comes in a black tub with gold writing lol cheesy name,tub and its expensive but works very very well without leaving your skin feeling oily which is what I hate about other face creams,its also long lasting just applying it once in the morning was enough to get me through the entire day without any signs of flaking/dry skin.
I've stopped using it though after I stopped roaccutane because my skin doesn't need it anymore.
 
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KevRSA said:
Well she said it was looking like a early case of cystic acne. I could definitely see that it was getting worse.

The only things she told me:

1) wash skin as usual, also use toner.
2) always moisturize a couple times a day
3) wear SPF 30+ sun screen
4) Don't drink (one at the most) :( :(
5) go for a liver test every month

and that's around it :erm:

anything I should Know?
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Be sure to take the not drinking part seriously. I was on this during my Matric year at school. My doc put me on 6 months. It stretched right over the Matric holiday as well. I was not happy with it at all, but it cleared up my skin completely.

Also, your lips is not the only thing that will become dry, other areas of skin will become dry as well. Also, be sure to not take in allot of other items containing Vitamin A.

Another side effect I experienced was lower back pain when lifting things.
 
Swa said:
That's just it. The packaging doesn't list all the side effects and it doesn't tell you they are permanent. On top of that the doctor makes it seem extremely safe.


And you're not reading or grasping what's said as usual.


I don't see why they should when dermatologists don't even do that.
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My dermatologist did before he would let me take it.
 
Another side-effect of roaccutane is that you cannot use it within at least 12 months of having a nose job as it has been associated with a higher rate of post-surgical tip deformities.
 
im chilled swa is just being annoying. he must be specific and not act like a nutcase
 
Honestly I was on Roaccutane for about a year and a half and think it was the best think I have ever done. Looking at the scaring my brother has because he didn't take it for long enough I am thanking my lucky stars.

... However, I was suicidal for almost the entire duration I was on it. It may however be unrelated, though, I doubt it.
 
RiaX said:
Once again you puny mind cant see reality. ok swa please explain the following:

1) How they found this drug

2) how they quantified its activity

3) How they made it selective to sebacious glands only

4) How they determined its chemical structure

5) How they refined it

See an innovative pharmaceutical company will pull the plug on its R&D of a drug once the project is complete. Its expensive and the human resource can be better used on the next project. The universities world wide handle the minor details (this is why they fund the schools of pharamacology and medical schools worldwide). So you have a grand misconception on what they mean by "Not fully understood" its not "we dont know a thing about it"

You really think they going to publish their sensitive information ? or waste their money on legalities.

so naive
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And how does any of that relate to the fact that the side effects I now have were not mentioned on the pamphlet or the fact that they are permanent? Oh it doesn't. :rolleyes:

This is just more rambling on your part with what has nothing to do with the topic again. Seriously starting to make me wonder about YOUR qualifications. Ok if you really must we have said for a long time that Roche has a pretty good understanding of how this works. The fact that they are not releasing that information despite thousands of us suffering from a medication they made billions off speaks volumes.

RiaX said:
ah its back ... Swa do you even know what it means ? define it and point it out for me. Clinical experience is not ad hominem or is stating the fact that you are lying and talking nonsense and extrapolating your experience as a norm. Poor intellect very poor
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And here you go with another one while on the subject. How wonderful. :rolleyes: Oh what a waste it is trying to debate with you.

RiaX said:
Well you believe in homeopathy and alternate medicine, yet you claim to use antidepressants and isotret and basically every single drug anybody has a question about. I can input on all of them because im a drug specialist its my job.... Also just because you had a dumb doctor that doesnt mean the entire world follows that procedure. Knowing you you probably moaned at the cost or had an know it all attitude so your Dr was like "F**k this oke leave him" .... we do that to people who think they know more medicine than people who are trained in medicine.
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Oh just STFU if you can't discuss the topic at hand. I've had it with all your insults and ad hominems.

RiaX said:
i have no intention of debating with you.
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Yes I know you're not. All you can do is insult and ridicule. Why don't you just go back to your PC forum? You are all those things you mention, hypocrite.

RiaX said:
Unfortunately vultures like you exist.
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Vultures? I don't get anything out of this. YOU however work for vultures mate. That's if you're not lying about your credentials like that wiki "professor".
 
Back to the topic. After my experience I really think this is a drug that needs reevaluating. It should not be used for mild breakouts like the docs are subscribing it for but only for the most severe cases. In case any one is wondering, I had one of these breakouts where my entire face was being covered and knowing what I now know I would not have taken it. That's how bad it can be if you're one of the unlucky ones.

@KevRSA: If you do take this stuff the advice is to start as low as you possibly can. 10mg at most and even 5mg if possible no matter what your doctor's opinion is. The doc/derm is the way to get it but YOU should be in charge of your dosage and duration. Don't go over 30mg and never take the full recommended dose of 1mg/kg as that's the doses I see people reporting these side effects at.
 
Swa said:
@KevRSA: If you do take this stuff the advice is to start as low as you possibly can. 10mg at most and even 5mg if possible no matter what your doctor's opinion is. The doc/derm is the way to get it but YOU should be in charge of your dosage and duration. Don't go over 30mg and never take the full recommended dose of 1mg/kg as that's the doses I see people reporting these side effects at.
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Interesting observation,I was on a pretty high dosage over 30 mg if i remember correctly and I had sever side effects(no suicidal tendencies etc thankfully but drying up of salivary glands) maybe a proper study should be done related to higher dosage of the stuff.
 
no matter what your doctor's opinion is. The doc/derm is the way to get it but YOU should be in charge of your dosage and duration.
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and this is why we have things like MDR XDR TB :cry: ..... utterly stupid

falcon786 said:
Interesting observation,I was on a pretty high dosage over 30 mg if i remember correctly and I had sever side effects(no suicidal tendencies etc thankfully but drying up of salivary glands) maybe a proper study should be done related to higher dosage of the stuff.
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study is done. It does alter brain chemistry hence its contraindicated in those with depression
 
falcon786 said:
Interesting observation,I was on a pretty high dosage over 30 mg if i remember correctly and I had sever side effects(no suicidal tendencies etc thankfully but drying up of salivary glands) maybe a proper study should be done related to higher dosage of the stuff.
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What I've been saying. This is from my informal study on the subject so we need proper ones with proper samples, but of course some pharmacists here know better. This isn't some dangerous thing like TB.

EDIT: Oh and the depression thing was studied in individuals with acne who are naturally more prone to depression so any otherwise noticeable effect would be negated by the acne being cured. If given to healthy patients instead I can guarantee there would be a noticeable increase in occurrences. This makes one wonder. Since the depression from acne is only temporary it's plausible there can be a higher rate of depression years later.
 
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ED50 swa ... go and learn.

A drug below a bioavailable plasma concentration will do nothing but damage the system and there will be no positive again. Especially one that competitively antagonizes retinoids.

Now stop sprouting nonsense. It becomes just as dangerous. You playing with S5 drugs as if you know something about them. How pathetic
 
hambone said:
Honestly I was on Roaccutane for about a year and a half and think it was the best think I have ever done. Looking at the scaring my brother has because he didn't take it for long enough I am thanking my lucky stars.

... However, I was suicidal for almost the entire duration I was on it. It may however be unrelated, though, I doubt it.
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well i was also in a similar situation but that is because i feared going out due to my acne. This drug literally saved my life, i don't think i could have carried on with that sort of acne for much longer. Back, chest, neck, face. It was an extremely trying time for me.
 
YOU are a pharmacist. You know even less on the subject. WE know because we were patients affected by it. Large dosages are dangerous. Small doses have also shown highly effective or even more effective as they don't come with the severe side effects so people are less likely to stop the course. It's also better to undergo a second or third low dose course rather than overdose in a single treatment. This is from patient experiences that your pharmaceutical companies have chosen to ignore. Of course it will be classified as S5 as it's a dangerous teratogen.
 
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killadoob said:
well i was also in a similar situation but that is because i feared going out due to my acne. This drug literally saved my life, i don't think i could have carried on with that sort of acne for much longer. Back, chest, neck, face. It was an extremely trying time for me.
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Yes this is when one must use roaccutane. When first and second line treatments have failed and the acne is extreme.

It has heavy side-effects but that is expected when you out of options. Isotret revolutionised dermatology wrt acne.

If you doctor puts you one this before using topical retinoids and tetracyclines ect then its poor practice.

People who don't have comestically disfiguring diseases can't understand the desire to rectify it. It can be devasting and the dangers of the drug are worth it for the desired prognosis.

So one must assess the benefits to risk before commenting on the point of the drug.

As per the side-effects most of the management has already been addressed.

Except for suicide. Should anyone have suicidal thoughts on this drug they must inform their doctors for appropriate management
 
Dude there was nothing that would have helped me. My doctor said there is a drug on the market to clear up your skin but it costs 1k a month, even though my folks were not in a great position they managed to find the money.

There was nothing else that was going to work, acne that extreme needs an extreme drug. Life saving one.
 
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