I'm using a single dedicated pc to download torrents from 2 sites and upload 2 the same sites. I use a single uTorrent 2.0 installation to service both sites.
I try not to upload the same files to the 2 sites, but it has happened. I then sit with 2 file names in the client that are same, but the tracker info obviously differ.
I also use Grabbit on the same pc to download from a local site and mainly 1 international site after I received a list of free nzb sites around the world that was recommended by Gary.

Obviously these free sites have their drawbacks when it comes to older nzb's.
I do not have any paid for news server accounts, but I'm still happy as Hdd space are my biggest problem currently.