A possible biological explanation for certain types of depression may be systemic inflammation.
http://archinte.jamanetwork.com/article.aspx?articleid=217001:
http://archpsyc.jamanetwork.com/article.aspx?articleid=1485898:
Here is a website that gives an "inflammation factor" of various common foods:
http://nutritiondata.self.com/help/inflammation
For example, pineapple has an inflammation factor of 65 making it mildly anti-inflammatory:
http://nutritiondata.self.com/facts/fruits-and-fruit-juices/2019/2
Salmon oil has an inflammation factor of 30284 making it strongly anti-inflammatory:
http://nutritiondata.self.com/facts/fats-and-oils/632/2
This may be the reason why many depression sufferers report that fish oil improves their depression.
This is very interesting.
The Marshall Protocol database (
www.mpkb.org ) concurs that it is indeed inflammation causing depression, and other chronic illnesses. It also describes
what causes that inflammation, it has a very detailed pathogenesis. It disagrees on how to best deal with this inflammation.
There are microbes in the body that deactivate certain receptors which deactivates your innate immune system, so the microbes proliferate. You still have an immune response, but it is fighting a losing battle. That 'battle', where your vitamine d receptors release anti-microbial peptides to destroy the microbes, and the die-off of the microbes which cause endotoxins and cytokines, are what causes the inflammation. This could be in the brain or elsewhere in the body (in which case one may have the 'diagnosis' of fibromyalgia, chronic fatigue, etc). It is also a very good explanation for what causes constant headaches (especially when other possible causes have been excluded). There are a great many new independent medical journals papers supporting this pathogenesis.
Anti inflammatories won't do the job - these microbes are systemic, and you can't rid of them that way. The best is to activate the body's own innate immune response, because anti-microbial peptides are the best at targeting and destroying these microbes.
Ons should also avoid vitamine D. Vitamine D is a secosteriod (a type of hormone) and not a much needed nutritional vitamine, unlike what we are 'spoonfed' all our lives, and keep on ingesting vitamine d enriched food. I am on my phone now, but if someone would like me to post medical journal articles to this effect later, I can.
Ons should also avoid ingested vitamine D. Salmon oil is extremely high in vitamine D, one of the highest of all foods. Humberto, this is where the Marshall Protocol disagrees.
One may ask: why do you feel better symptomatically after ingesting/getting vitamine D? It is because you are shutting down your innate immune response, and there is no more 'battle' against the systemic microbes in the body (read: brain - ie your depression might lift for a while), ergo no more endotoxins and cytokines, ergo less inflammation, ergo less depression/pain. BUT the microbes are now left to proliferate more quickly, so in the long run you are disadvantaged.
Low vitamine D is associated with depression and chronic illnesses - that does not mean it is the cause. Correlation is not causation. Supplementing with vit D will make things worse, ultimately. As explained in above paragraph. Doctors can test your vit D levels (the '25-D' blood test) but they don't test the 1,25-D blood levels, which will be high in a patient with chronic inflammatory diseases (which very much includes systemic depression). Unfortunately in RSA, it is only the NHI who test the 1,25-D, and they almost always botch it up.
I am not a doctor, just a patient who is learning my condition. And my wife's. The Marshall Protocol treatment is very tough in the beginning, but you will be cured and returned to a normal life.
I am only posting this for people's benefit who don't get adequate help from 'status quo' medicine. (The Marshall Protocol, even though more than 10 years going, is slowly being accepted world wide as the best explanation and body of knowledge for chronic inflammation)