Endometriosis is most likely caused by a hormone imbalance, basically boils down too much estrogen and too little progesterone. That is why it will keep returning. Endometriosis itself, and its hormonal origin, may both cause some of the problems.She has endometriosis. Causes abnormal pain during menstruation. Had multiple surgeries during her life and it just returns after a while.
Has she tried high doses bio-identical progesterone? On the one end it will balance the estrogen, but it act as a precursor to many steroidal hormones and it will also have a calming effect in the brain by converting to allopregnanolone.
https://naturone.com/sa-products/ This is the one me and people I help out uses.
I'm not a doctor, but have quite a bit of experience with steroidal hormones. Ironically more with the female hormone system than with the male.