some motherboards you can do this already
I know
http://www.gigabyte.com.tw/Products/Storage/Products_Overview.aspx?ProductID=2678&ProductName=i-RAM%20BOX
Wikipedia:
Second Generation i-RAM
The second generation i-RAM, GC-RAMDISK, was on display at Computex 2006 [3] [4]. Rather than using a PCI slot for powering the drive, Gigabyte had implemented the GC-RAMDISK as a 5.25" drive unit powered from a four-pin molex connector. The drive supports four DDR2 memory modules of up to 2 GiB for a total capacity of up to 8 GiB and the interface supports SATA II, which doubles the transfer rate compared to i-RAM.
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