Tramadol

[DrewChan]

*Finishes popcorn

Riax, taking your word that you have honours etc etc. I would have expected you to become more patient with people and rather educate those that you perceive as wrong or wish to debate you.This will serve you far better than name-calling and insulting.

Defending your opinions so vehemtly and bashing anyone that disagrees makes you seem more like a basement dweller who tries to live behind an assumed identity.

(Hence people questioning your integrity)

Just my 2 cents.

 

[copacetic]

I just checked SAMF and its under analgesics:

Tramadol: is an atypical opioid structurally akin to tilidine. It falls under other opiates... not Benzomorphan derivatives.(But that is right next to it so probably very close)

Thank you.

Saves me a trip to my chemist.

*edit*

Just so we're clear, this quite obviously shows that the claim:

Secondly tramadol is a benzomorphan

Is bull****...

Get off your high-horse, maybe?

 

[killadoob]

Thanks Killa. Just had two tabs but it's rather for prevention against new outbursts than than cure. Hmm, had too much cake, ice cream, choc and dairy the last two weeks. Thats probably why.

There is no cure dude, only prevention.

Copa pwned him with dignity bro, way worse than tuning him outright but ya his horse is looking more like a pony

 

[wily me]

There is no cure dude, only prevention.

Copa pwned him with dignity bro, way worse than tuning him outright but ya his horse is looking more like a pony

Looks like this thread is the druggies against the pharmies. LOL

Wheres the popcorn.

 

[RiaX]

I just checked SAMF and its under analgesics:

Tramadol: is an atypical opioid structurally akin to tilidine. It falls under other opiates... not Benzomorphan derivatives.(But that is right next to it so probably very close)

What edition samf was this?

Benzomorphans are opitate derivates ... they are synthetic opiates BTW.

They are antagonist-agonist drugs that work on the opiate receptors. A closely related drug to the family is phenazocine. These substances are derived synthetically from the morphine structure. Tramadol is a drug that does this hence why its grouped with them (lippinocotts illustrated pharmacology groups them according to activity and tramdol is grouped with the benzomorphan group but they are all opiate analgesics).


tramadol structure:

http://structures.wishartlab.com/molecules/DB00193/image.png

now tramadol in the capsule you take it is as racemic mixture, basically meaning its mirrored chemically in structure. So it can be dificult to see its similarities, but if you look carefully you can see its relation to the morphian family which benzomorphans are a part of. Now because the nature of how trmadol is prepared if you go hunting for its structure you going to find many different looking pictures but they are isomers (S and R)

Phenazocine (a true benzomorphan): structure:

http://forendex.southernforensic.org/C/dl58.png

or use wikipedia for a bigger picture (lol)

http://upload.wikimedia.org/wikipedia/commons/d/dc/Phenazocine.png

Now the key is the nitrogen when identifying opioids, that makes what is known as ring E if its disturbed there is no activity in the opioid at all, so it must be present in the ring system. Its the bridge that allows the compound to interact with opiate receptors (I call it a bridge I forgot whats its proper name is. Makes life easier to know its bold notation when drawing it) that bridge relation to the nitrogen is key.

this is how to make a benzomorphan: (I dont have a scanner, ok lies i do im too lazy to scan )

And as I said earlier

If you really want to know, then you have to look at its chemical structure to see why its classified as a benzomorphan. It belongs to that family of drugs even though its not a direct member its a cousin per say. Its one of those dual action drugs that works on a series of pathways from opioid to actylcholine receptors and many more.

Its activity is comparable to codiene in other words similar to that of a low ceiling opioid if you look at its structure you can see the basic structure of an opioid as well.

Anyways I didnt classify it, thats just how its classified in text.

and

its a synthetic miscellaneous compound... The SAMF defines is under the benzomorphans

So unless my SAMF is out of date and its suddendly changed into a proper opioid (like morphine) then maybe I should go shopping for a new samf

though I doubt tramadol has changed its structure and my SAMF is pretty new, was planning to buy the newer one this week anyways. So as I said tramadol is a benzomorphan .... but not a true one but a cousin

that my lecture for the day.... phew okes are keeping me sharp in academic knowledge here D:

 

[copacetic]

So it's not classified as a benzomorphan, as you initially claimed?

Thanks....

*edit*

I don't know why you are waffling about all the rest of the stuff, as all I asked you was regarding the classification you initially claimed. All the rest of it, I (and anyone else) am/are probably perfectly capable of researching themselves, if we wish.

 

[Nerfherder]

My SAMF is old... but I doubt these things change LOL

 

[killadoob]

So it's not a benzomorphan, as you initially claimed?

Thanks....

LOLz, some people can never admit to mistakes. Fight tooth and nail to prove their obvious mistake.

Nerf i think we need a scan from riax or we can assume he is wrong.

 

[copacetic]

that my lecture for the day.... phew okes are keeping me sharp in academic knowledge here D:

We don't need to be lectured, thanks.

 

[Nerfherder]

LOLz, some people can never admit to mistakes. Fight tooth and nail to prove their obvious mistake.

Nerf i think we need a scan from riax or we can assume he is wrong.

I'll scan... but will see if I can get an update SAMF.

 

[crysis]

No you THINK I've made mistakes but I actually havent. This is what happens when you not qualified and think you know something. You aware you get IUPAC names ? structural names? pharmacological classification ? ... but you wouldnt be able to to tell the difference because sites like wikipedia dont teach you these things as they are not lessons in medicinal chemistry. Secondly all journal articles intended for the field assume you have the knowledge as basic as this.

Tramadol is classified as a benzomorphan according to the SAMF if you dont like it send them an angry email. Im not wasting my time engaging with a person who thinks he is a specialist after reading 2 or 3 articles on a subject

I've read a few of your posts, and I must say, I've never seen any one talk as much k*k as you since malema got kicked out the ANC youth league. Get off your high horse please.

 

[drkev]

 

[RiaX]

My SAMF is old... but I doubt these things change LOL

I doubt tramadol changed but again as I said its one of those. Compounds that doesn't have a true class. In terms of struture. In terms of pharmacological activity its classed as a benzomorphan.

 

[RiaX]

I've read a few of your posts, and I must say, I've never seen any one talk as much k*k as you since malema got kicked out the ANC youth league. Get off your high horse please.

And how would you know ?

 

[RiaX]

We don't need to be lectured, thanks.

And that's why you don't understand. You think everything is black and white. Pharmacology and chemistry and complex sciences

 

[copacetic]

In terms of pharmacological activity its classed as a benzomorphan.

How is it that the entire internet disagrees with you, the SAMF disagrees with you, and most importantly why are you shifting the goalposts of your initial (incorrect) claim?

 

[copacetic]

And that's why you don't understand. You think everything is black and white. Pharmacology and chemistry and complex sciences

What precisely, pray tell, don't I understand? :wtf:

This is a very simple argument.

You said Tramadol is classed as a benzomorphan, and I asked if you were sure. That is indeed black and white, although, you claim that I view things in black and white, which is not the case in general, only in relation to this specific statement on your part.

 

[killadoob]

And that's why you don't understand. You think everything is black and white. Pharmacology and chemistry and complex sciences

So no scan to back up your claims yet, just more yada yada. More scan less yada yada

 

[RiaX]

What you don't understand is I was refering to activity of tramadol. Benzomorphans are agonist-antagonists and tramadol is a agonist-antagonist of opioid receptors. The person posting about tramadol doesn't need to know its structure.

Tell me what YOU understand as a benzomorphan ?

 

[copacetic]

What you don't understand is I was refering to activity of tramadol. Benzomorphans are agonist-antagonists and tramadol is a agonist-antagonist of opioid receptors. The person posting about tramadol doesn't need to know its structure.

Tell me what YOU understand as a benzomorphan ?

Your logic now seems to be something along the lines of 'Fords and Toyotas both have four wheels, therefore a Ford is a Toyota'...

What do I understand what is meant by a benzomorphan? Only what the internet defines it as, I'm not a chemist:

any of a group of synthetic compounds including some potent analgesics (as phenazocine or pentazocine)

6,7-Benzomorphan; 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine;the parent compound of a series of analgesics including pentazocine and phenazocine; it does not possess analgesic properties itself.

...