Biohacking/Longevity and reversing aging

Zukat said:
How is death different from other diseases that have been cured already?
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Because it's not a disease and even it it were there's plenty of those that doesn't have a cure. Thinking of death like it is influenza is very ignorant.
 
Research from scientists at the University of Chicago revealed that intermittent fasting can “delay the development of disorders that lead to death. There’s evidence that people who fast regularly can enjoy a longer, healthier life than people who eat a regular three meals a day. Or those who follow a traditional restricted-calorie diet.

Head of the National Institute on Aging’s neuroscience laboratory, Mark Mattson, says the mild stress that intermittent fasting puts on the body provides a constant threat. This increases the body’s powerful cellular defenses against potential molecular damage. Intermittent fasting also stimulates the body to maintain and repair tissues. It’s anti-aging benefits, keep every organ and cell functioning effectively and efficiently.

http://www.longevitylive.com/most-popular/10-reasons-to-practice-intermittent-fasting/
 
Tim Ferris has been looking at this as have a bunch of the very rich. Obviously results vary and it's difficult to pinpoint which (if any) technique works because you kinda need to wait until they die. The lack of scientifically useful data isn't because nobody is trying but because nobody has come up with something that meets criteria for "proof".
 
wizardofid said:
Then you end with a genetic issue, get run over by a car, brain clot, myocardial infarction or worse unexpectedly die unrelated to a healthy living, and as direct result of weight training, arthritis or other joint related issues.

There is a point where it is excessive, you pretty much done that...;)

Some myths to clear up red wine does have Antioxidants but not that rich a ORAC score of around 3670, in fact you better off with a fruit based wine instead of a grape based wine as it has a ORAC score 4 times higher or more.

Much much healthier option is just eating blueberries or sucking on clove or clove oil, with cloves having the highest ORAC score and you don't poison your self with alcohol ;) Even dark chocolate or plain cocoa has a higher score

While water is fine, liquid intake isn't exclusive to to plain old water, caffeine free coffee and teas like green and rooibos(Also rich Antioxidants more then wine) also counts towards liquid intake, unsweetened fruit or vegetable juices also count towards intake.So you are really not doing your self any favors by limiting your fluid intake to just water.

Fast foods, every now any then is good for you, you shouldn't be cutting fats out of your dieet, vitamins A D E and K are fat soluble and actually need it ;) So that portion of take away food every now and then isn't entirely bad.
Olive oil or grape seed oil in your daily dieet :)

Shame health nuts punishing them self for no apparent reason......other then prolonging their suffering....
Not sure what you are trying to achieve here,
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You bringing up good points, but a lot of what you mentioned I summarized with the "nutritious diet" as its a big write up and there is a lot of information on that already (having the balance between protein/carbs/fats)

To your point around doing all this and then get run over by a car- obviously "Luck" is a big component in this whole process, but I try to focus on what I can control and taking precautionary measures to avoid high risk circumstance (like for example spending more just to drive an SUV instead of a sedan etc.)
 
The social implications of life expectancy even just extended to 120 years, has not been explored.
The whole idea of 65 being the retirement age, will have to go away. Myself - my goal is that by 65, I only work because I want to.
Retiring and spending my days on a gold course, would be the death of me.
 
Having been interested in longevity and nootropics for a long time, I have slowly added quite a few interventions. Part of it is the basics like exercise, meditation, minimizing junk food, sleeping enough, drinking enough fluid(fresh veggie+fruit juice, water, rooibos, and a little coffee). Unfortunately that is not going to be enough, if it was, someone would have figured it out by now. So my current stack looks like this. Things get added and removed on a regular basis, but this is it for now. Some of it is more for cognitive enhancement though.

Melatonin 0.5mg/d
Ginkgo Biloba 250mg/d
Spirulina 2.5g/d
Chlorella 1g/d
Vitamin A 2000iu/d
Vitamin C 1.5g/d
Vitamin D3 10000iu/d in Winter - 5000ui in Summer
Vitamin K2 1300µg MK4 & 100µg MK7 /d
Lithium Orotate 5mg p/d
MSM 1g/d
B-complex 1x Vitacost capsule
Omega3 2ml /d
Homemade C60oo 5 mg /week
Magnesium sulphate 1g/d
Sodium tetraborate 50mg/d
Selenium 200µg/d
Chromium 24µg/d
Zinc 14mg/d
Iodine 3-5mg day
Probiotic
Potassium Chloride 1g/d
Niacinamide 500mg/d
Citric acid 1g/d
PQQ 10mg/d

Cycled
Epitalon
Pinealon
Cortagen
Nasal Insulin
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Selegiline will be added soon, and if I get no big side effects, I will keep using. Also in the next year I plan to add intermittent use of Rapamycin, but I still need to study it and the mTOR pathways a bit more. I'm still in 2 minds about Metformin, because it may have some effects that can clash with other things I'm trying to accomplish. But on the other hand, it my synergize very well with Rapamycin.

In the longer term, Foxo4dri looks very promising and so do GDF-11. I don't think those are going to help me much for now, but in 5-10 years, if no research contradict it, I will probably test it.

Some of the SENS research are interesting, but it will be quite a while before there is anything I'll test. CRISPR and mRNA carried my AAVs are really interesting avenues, but its going to be a while before I'll actually do that on myself.
 
Nuke said:
Having been interested in longevity and nootropics for a long time, I have slowly added quite a few interventions. Part of it is the basics like exercise, meditation, minimizing junk food, sleeping enough, drinking enough fluid(fresh veggie+fruit juice, water, rooibos, and a little coffee). Unfortunately that is not going to be enough, if it was, someone would have figured it out by now. So my current stack looks like this. Things get added and removed on a regular basis, but this is it for now. Some of it is more for cognitive enhancement though.



Selegiline will be added soon, and if I get no big side effects, I will keep using. Also in the next year I plan to add intermittent use of Rapamycin, but I still need to study it and the mTOR pathways a bit more. I'm still in 2 minds about Metformin, because it may have some effects that can clash with other things I'm trying to accomplish. But on the other hand, it my synergize very well with Rapamycin.

In the longer term, Foxo4dri looks very promising and so do GDF-11. I don't think those are going to help me much for now, but in 5-10 years, if no research contradict it, I will probably test it.

Some of the SENS research are interesting, but it will be quite a while before there is anything I'll test. CRISPR and mRNA carried my AAVs are really interesting avenues, but its going to be a while before I'll actually do that on myself.
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That looks expensive. How much does it cost you per month?
 
Zukat said:
I am 31 and had an opportunity to do a DNA blood test with a result of 26.2, the feedback Im getting is I look in my mid twenties. I attribute this feedback mostly to Niagen (been taking over a year) and healthy diet and activity (been training since 20).
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With all the effort you're making unless they're saying you look like a teenager you're wasting your time :erm:
 
rietrot said:
Because it's not a disease and even it it were there's plenty of those that doesn't have a cure. Thinking of death like it is influenza is very ignorant.
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Isnt being ignorant taking death as default consequence and not even making an effort to try and challenge it? Yes there are plenty of disease that dont have a cure yet, so lets rather just accept and not do anything about it.
 
Zukat said:
What Im already practicing:

1) No smoking. No fast food.
2) Nutritious diet with combination of protein shakes, broken down into 5 daily meals
3) 1-3 glasses of red wine per week proven to be more healthier than not drinking at all
4) Weight training 5-6 days a week
5) At least 3L of water daily, no other liquids
6) Supplements: multivitamin, salmon oil/omega 3, vitamin C
7) Niagen (helps damaged cells repair themselves)

After human trials looking to introduce Foxo4dri peptide, currently I found only 1 person experimenting with it with significant positive health improvement results
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You already died inside. Drowning seems to have been the cause of death.
 
ShaunSA said:
With all the effort you're making unless they're saying you look like a teenager you're wasting your time :erm:
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Well, if you look through history people who tried to challenge the default/traditional way of life have always been mocked and considered foolish until there was a breakthrough, then suddenly their status changed to a visionary... besides how is feeling great daily a "waste of time" with potential future benefits?

Anyway, living a healthy life is good and all, but damn, you have to enjoy life as well. Sure, some things are just stupid, like smoking and doing the more dangerous drugs.
I'm just not going to not drink beer, not eat pasta and or red meat and chocolate cake every now and then due to the 1% extra chance I will die before 70.
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The funny thing is I do enjoy this lifestyle, I guess its a matter of priorities similar to debate around buying a sports car or investing that money for retirement. For me the benefit of enjoying my time and experiences in this place with family/kids outweighs any other short lived joys.
 
I'm sorry, but this is flesh. It is made to decay.

It seems the only way to get functional "immortality" would be a non-biological vessel for...err...for the brain?

Is the brain the centre and totality of the self?

And what about all those nonhuman lifeforms, as I mentioned earlier - do they get a pass on death as well?
 
ShaunSA said:
With all the effort you're making unless they're saying you look like a teenager you're wasting your time :erm:
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Lol.
Because you're only healthy if you look young?
Would you only stop smoking if it meant you'd look like a teenager?
 
Aquila ka Hecate said:
I'm sorry, but this is flesh. It is made to decay.

It seems the only way to get functional "immortality" would be a non-biological vessel for...err...for the brain?

Is the brain the centre and totality of the self?

And what about all those nonhuman lifeforms, as I mentioned earlier - do they get a pass on death as well?
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I hear your point, at the end its about our conscious that makes us, so future advancements and ability to upload your brain will theoretically allow you to replicate yourself in any vessel form you want, so the longer you can stay here the more chances you would experience that realization.
 
Zukat said:
I hear your point, at the end its about our conscious that makes us, so future advancements and ability to upload your brain will theoretically allow you to replicate yourself in any vessel form you want, so the longer you can stay here the more chances you would experience that realization.
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I was quite heavy into the Longecity (old Imminst / immortality institute ) forum years ago. The upside of it was the start of eating clean and eating a wide variety of whole foods and paying attention to the health & maintenance of this biological machine that is my body.

I was struck by how much time I'd put into say, tweaking my computer for optimal performance, but gave almost zero attention to this body. People put so much attention into giving their car the best oil, or their pc the best components but don't think twice about what they're putting into their bodies - as though it doesn't matter.

It would be nice if good health could get us just to the point where technology can intervene and take us further, and I'd be up for that. But I don't know if we'll see such advances in our lifetime.
 
Darn it. I should have stopped reading at post 3 in this thread. Now I am finding myself googling this stuff.
 
saor said:
I was struck by how much time I'd put into say, tweaking my computer for optimal performance, but gave almost zero attention to this body. People put so much attention into giving their car the best oil, or their pc the best components but don't think twice about what they're putting into their bodies - as though it doesn't matter.
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Because they are passionate about something, this should be obvious.

If your goal in life is to live forever, what is the point of living forever?

I haven't spent a lot of time on the concept of living forever but essentially every cell in your body is programmed to die so that you can live longer. Cancer is inevitable in mammals, the risk for cancer is greatly reduced by aging. If you don't want cancer you need to spend more energy to prevent mutation which means no horizontal DNA transfer, nor the advantages provided by genetic mutation.

Your evolution would stand still (like the crocodile) while every species around you would surpass you.

IMO based on our level of improvement preventing aging is inevitable but almost certainly it will likely end up with people that are out of place, unable to adapt as well as the next generation and inevitable cause our species to slow down.

For the sake of our species, "solving" aging is bad in so many ways.
 
Also wanted to add, if you plan on living forever, you need to fundamentally shift your thinking.

Most older people struggle to fit in because they are set in their ways. Like it or not, every fad you think is stupid or technology you think you can give a "skip" is essential to keep progressing with the rest of the people on this planet.

Nothing is more sad than seeing old people in a store that don't understand a card machine, can't use a computer, etc.
It started simply and suddenly 20 years later they were completely unprepared.

If you are stubborn right now and unadaptable. If you find yourself talking about those "nerds" that know enough about computers so that you can call them up to fix your "problems" for you, you are in trouble in 30 years. At that point your little problems will be something everyone can do and they'll look down on you and simply will not waste their time on your problems. They want to keep moving afterall

This is just an example, but there are certainly going to be other examples that are more social (eg. texting instead of speaking), etc.
 
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