Biohacking/Longevity and reversing aging

Weight/strength training may be a great component for functional fitness, and to keep the body balanced and strong. But, cario is still required. You do not get fit by picking up weights. Aesthetically, weight training is the way to go, but for overall health, a balanced and varied regimen is far better.

Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging
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Physical exercise, particularly aerobic exercise, is documented as providing a low cost regimen to counter well-documented cognitive declines including memory, executive function, visuospatial skills, and processing speed in normally aging adults. Prior aging studies focused largely on the effects of medium to long term (>6 months) exercise training; however, the shorter term effects have not been studied. In the present study, we examined changes in brain blood flow, cognition, and fitness in 37 cognitively healthy sedentary adults (57–75 years of age) who were randomized into physical training or a wait-list control group. The physical training group received supervised aerobic exercise for 3 sessions per week 1 h each for 12 weeks. Participants' cognitive, cardiovascular fitness and resting cerebral blood flow (CBF) were assessed at baseline (T1), mid (T2), and post-training (T3). We found higher resting CBF in the anterior cingulate region in the physical training group as compared to the control group from T1 to T3. Cognitive gains were manifested in the exercise group's improved immediate and delayed memory performance from T1 to T3 which also showed a significant positive association with increases in both left and right hippocampal CBF identified earlier in the time course at T2. Additionally, the two cardiovascular parameters, VO2 max and rating of perceived exertion (RPE) showed gains, compared to the control group. These data suggest that even shorter term aerobic exercise can facilitate neuroplasticity to reduce both the biological and cognitive consequences of aging to benefit brain health in sedentary adults.
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https://www.frontiersin.org/articles/10.3389/fnagi.2013.00075/full

saor said:
Would you sign up for an extra 500 years of healthy living?
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Yes, please. My life does not revolve around the consumption of food.
 
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saor said:
Would you sign up for an extra 500 years of healthy living?
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How much would it cost?

500 years is hard to survive

How would this impact the economy? Would I want to live in a very overpopulated world?
 
static_sa said:
How much would it cost?

500 years is hard to survive

How would this impact the economy? Would I want to live in a very overpopulated world?
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I always get the impression that this would not be a problem.
It's obviously only meant for the well-to-do.
**** the poor and disadvantaged, you know.
 
saor said:
That's also just a bull**** platitude. I don't think cola is good in moderation, or twinkies or crack is good in moderation. 'Everything is good in moderation' only works when the overwhelming majority of stuff we can choose from is healthy whole foods. When the majority is refined junk then no, not everything is good in moderation.
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:confused:
I think you are getting the words moderate and moderation a little mixed up.
Everything in moderation, does not equate to moderate amounts of those things, being good or bad.

In context of the discussion, It means to take into account and assess the potential impact on your body, the food/liquid you take in.
In context, a moderate amount of coke could be once a month or even once a year, depending on how your body reacts to it.

Everything in moderation, means to not exceed the limits at which extremes can be handled.
It's not a platitude, it is something in which there is a subjective measurement made by each individual on what the limits are and what constitutes moderation.
 
Aquila ka Hecate said:
...
**** the poor and disadvantaged, you know.
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There is only so long that those who are incapable, unlucky or unwilling can be carried into the future. To put it bluntly, the poor, disadvantaged etc. **** themselves by simply being not important enough to be cared about in terms of ****ing over.

Truly, where is the value in shooting a man in the foot when he has 2 shotguns aimed downwards already. These victim conspiracies are only there to placate those who cannot or will not take responsibility for themselves.

Additionally, it would be quite a thing to be able to live to 500 years, not every person will have the mental fortitude to handle it, regardless of wealth or other attributes.
 
DMNknight said:
:confused:
I think you are getting the words moderate and moderation a little mixed up.
Everything in moderation, does not equate to moderate amounts of those things, being good or bad.

In context of the discussion, It means to take into account and assess the potential impact on your body, the food/liquid you take in.
In context, a moderate amount of coke could be once a month or even once a year, depending on how your body reacts to it.

Everything in moderation, means to not exceed the limits at which extremes can be handled.
It's not a platitude, it is something in which there is a subjective measurement made by each individual on what the limits are and what constitutes moderation.
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The right amount of Coca Cola to drink is 0.00000ml. There is no moderate amount of Coca Cola that is "good" for you. It is not like you will see health benefits if you drink one can a day. You will see health problems even from one can a day.

So, I agree, for some things, moderation is not applicable. KFC for instance. No amount of KFC is good for you. Ideally you should never eat it.

Will a can of Coke and a box of KFC every 3 months kill you? No, but it isn't good for you either.
 
The body is incredibly resilient. Please don't confuse "not good" with harmful either.

Coke isn't good for you, but depending on the person, it is also not necessarily or only temporarily bad for you.

But in dire circumstances, should you be starving and near to death, KFC and coke would give you enough to stave off death for a day or two, perhaps long enough to find more sustenance. You may even live long enough to die from scurvy ironically ;)

Whole hearty food is obviously the ideal because thats what we've been eating all along. Fast foods are are very very recent thing.
 
DMNknight said:
There is only so long that those who are incapable, unlucky or unwilling can be carried into the future. To put it bluntly, the poor, disadvantaged etc. **** themselves by simply being not important enough to be cared about in terms of ****ing over.

Truly, where is the value in shooting a man in the foot when he has 2 shotguns aimed downwards already. These victim conspiracies are only there to placate those who cannot or will not take responsibility for themselves.

Additionally, it would be quite a thing to be able to live to 500 years, not every person will have the mental fortitude to handle it, regardless of wealth or other attributes.
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Jesus.
 
maumau said:
That looks expensive. How much does it cost you per month?
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I try to keep the longevity part to about the price of a packet of cigarettes per day. But seeing that I'm experimenting, it may end up a bit higher.
Some of it is a bit hard to calculate, I prefer to buy in bulk, seeing that the once of cost is pretty high, but then it lasts years. Eg. I payed around R12K for the manufacturing of the Epitalon, I don't like the idea of buying from a peptide site where I can't be sure about quality, or where I know they have not removed the TFA. I have been using it for 2 years already, and I have more left in the freezer. It may degrade a bit over time, but precise dosing is not that important.

The longevity is just part of when I'm trying to achieve. More important than lifespan is actually healthspan. I'm trying to increase my cognition, mood, physical performance, sexual wellbeing and mental health in the long run. All of it is possible to hack by some way or another.
 
Nuke said:
I try to keep the longevity part to about the price of a packet of cigarettes per day. But seeing that I'm experimenting, it may end up a bit higher.
Some of it is a bit hard to calculate, I prefer to buy in bulk, seeing that the once of cost is pretty high, but then it lasts years. Eg. I payed around R12K for the manufacturing of the Epitalon, I don't like the idea of buying from a peptide site where I can't be sure about quality, or where I know they have not removed the TFA. I have been using it for 2 years already, and I have more left in the freezer. It may degrade a bit over time, but precise dosing is not that important.

The longevity is just part of when I'm trying to achieve. More important than lifespan is actually healthspan. I'm trying to increase my cognition, mood, physical performance, sexual wellbeing and mental health in the long run. All of it is possible to hack by some way or another.
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Yes, it's expensive getting the groundwork done on anything new, but once you're set up away you go.

Your lifestyle isn't costing too much.
 
terencej said:
Tsek GNOME. I want to Live forever!! I will adapt.
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That's the spirit, that is what keeps our species going!

Bobbin said:
But to be fair, if I can't afford something in my private capacity it is largely my own fault too. (With luck element thrown in - but such is life :/)
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Every single person in life that is successful is IMO 90% down to chance.

My friend used to say, being born ugly means playing life on the hard setting. Being born ugly and stupid is playing life on the nightmare setting. Being an attractive white female, in our current world, is pretty much the equivalent of winning the lottery.

Now imagine being born in an African village without electricity compared to begin Ozzy Osbourne's child or etc.

Sure working hard gets you places.
A lot of successful people attribute to hard work. Like everyone who hasn't been successful in the past were just lazy.

Right time, place, people around you, etc. plays an enormous role in the outcome.
Precious few people are in the position to control those factors.

Sure there are people that are lazy but a lot of people in this world work incredible hard and basically it doesn't get them anything or anywhere.

Tis life.

Having as many children as possible is pretty much the spray and pray strategy to this. Or more scientifically, they are selecting r over K (obviously humans are K as a whole but some people are in it to win it, baby wise)

Having argued this, I imagine if some more advanced species were watching us they would be as likely to recognize individual contributions as we are with ants. Which is to say, as a species we make progress, but really individuals are but a grain of sand and probably got lucky anyway.
 
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Gnome said:
Every single person in life that is successful is IMO 90% down to chance.

My friend used to say, being born ugly means playing life on the hard setting. Being born ugly and stupid is playing life on the nightmare setting. Being an attractive white female, in our current world, is pretty much the equivalent of winning the lottery.

Now imagine being born in an African village without electricity compared to begin Ozzy Osbourne's child or etc.

Sure working hard gets you places.
A lot of successful people attribute to hard work. Like everyone who hasn't been successful in the past were just lazy.

Right time, place, people around you, etc. plays an enormous role in the outcome.
Precious few people are in the position to control those factors.

Sure there are people that are lazy but a lot of people in this world work incredible hard and basically it doesn't get them anything or anywhere.

Tis life.

Having as many children as possible is pretty much the spray and pray strategy to this. Or more scientifically, they are selecting r over K (obviously humans are K as a whole but some people are in it to win it, baby wise)

Having argued this, I imagine if some more advanced species were watching us they would be as likely to recognize individual contributions as we are with ants. Which is to say, as a species we make progress, but really individuals are but a grain of sand and probably got lucky anyway.
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Ok so instead of 5 starving people we should breed and create 20 more with even worse circumstances and luck sharing the same resources :( If push comes to shove, I might choose extinction over suffering.

Maybe Agent Smith was right :p

[video=youtube;IM1-DQ2Wo_w]https://www.youtube.com/watch?v=IM1-DQ2Wo_w[/video]
 
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If you thought I take a load of things, check out this guy. Though I'll get there, one day I guess :p

https://hackernoon.com/im-32-and-sp...er-extroverted-healthier-happier-2a2e846ae113

Just a small disclaimer. Just because I take something does not mean anyone should. Some things have special considerations - Iodine for example. You have to take it with selenium, and I would suggest very slowly increasing your dose. It took me 1.5 years to get to 1 drop (5mg) a day. One of my friends had a nasty auto immune response when he started off taking 5mg a day without selenium.
 
Nuke said:
If you thought I take a load of things, check out this guy. Though I'll get there, one day I guess :p

https://hackernoon.com/im-32-and-sp...er-extroverted-healthier-happier-2a2e846ae113

Just a small disclaimer. Just because I take something does not mean anyone should. Some things have special considerations - Iodine for example. You have to take it with selenium, and I would suggest very slowly increasing your dose. It took me 1.5 years to get to 1 drop (5mg) a day. One of my friends had a nasty auto immune response when he started off taking 5mg a day without selenium.
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Supplements are just a very small portion of the equation. You don't need to spend a huge amount of money to get some of these benefits. Get out and move more.

And this guy is super fit. A Vo2max of 70 is very impressive and not far off from the pros. Top vo2max records top out at 97.5 (for men).
 
Eish, its quiet here. If I look at the amount of response here and how few SA users are on forums like Longecity, I get the feeling that most South Africans are not interested in longevity and enhancing themselves.

[video=youtube;avoHaUbECLQ]https://www.youtube.com/watch?v=avoHaUbECLQ[/video]

Well, seems like her gene therapy is doing something. For now I have no use for telomerase therapy, it may even be totally redundant seeing that I use Epitalon, but good to know anyway.

Athletes will probably love her follistatin treatment, just that may be a great market on its own.
 
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