Diwali Fireworks

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Silencers... ever heard of 'em? You know, those things in vehicles' exhausts which keep noise levels within reasonable limits?

I know it's asking a lot, but at least try to fake some basic cognitive function. :rolleyes:

Take your own advice
 
You're not a layman. You're an expert. On everything. Like speed measurent.

You should check out his posts from another forum. He qualified as a pharmacist in 2008/2009. Late last year he was still a locum pharmacist who at one stage claimed that ketones cause a condition called atherosclerosis, which is complete horseschit, and then went on to state that that's why people take aspirin for the treatment of the syndrome. Oh, and he claims to be a professional magician as well. And now he is a researcher of everything we discuss on the forums, and his research is peer-reviewed by people from around the world.

Hilarious stuff...
 
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http://health.nytimes.com/health/guides/disease/type-1-diabetes/complications.html

lol yeah keep going bud. Guess they call it ketoacidosis for fun :rolleyes:

and yeah diabetics using asprin as cardio protection is totally a myth :rolleyes:

http://www.foodnetworksolution.com/uploads/vocab/9dfe3a3f64a43cf52d8a0c24a320909c.JPG

play spot the ketone LOL can you ? do you even know what a ketone is ?

LOL @ silent cars .... wow

Like 3-and-a-bit years of legal study at 'varsity.

What law was this ? didnt finish it?
 
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http://health.nytimes.com/health/guides/disease/type-1-diabetes/complications.html

lol yeah keep going bud. Guess they call it ketoacidosis for fun :rolleyes:

and yeah diabetics using asprin as cardio protection is totally a myth

LOL @ silent cars .... wow

None of that in any way whatsoever points to ketones causing atherosclerosis. It is rather fascinating how a pharmacist can misunderstand parts of an article addressing the risks of KETOACIDOSIS in diabetic patients so abominably. Ketones do not cause hardening of arterial walls. How can you defend this?! It's just horseschit based on a severe misunderstanding of an incredibly basic bit of anatomy and biology on your part.

Moreover, that article is chock full of falsehoods, fallacies and antiquated crap that I was nearly shocked that you even quoted it. Then I came to my senses about being shocked...
 
and yeah diabetics using asprin as cardio protection is totally a myth :rolleyes:

I didn't say that it is. This is your fundamental problem. Your comprehension skills are abominable...
 
LOL spoken like a true idiot.

You think these processes of fat metabolism are separate ?

now you understand why Drs dont bother to educate their patients.... its not arrogance its simply way above your head

Moreover, that article is chock full of falsehoods, fallacies and antiquated crap that I was nearly shocked that you even quoted it. Then I came to my senses about being shocked...

Lol thats a simple explaination I didnt really read it I dont need to. Though it would be interesting for you to point out the fallacies you think it has. lets see what you THINK you know

but hey you know more than these guys

Review Date: 5/22/2012
Reviewed By: Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

they just wrote the article ... lmao

you still havent pointed out the ketone .... :p
 
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You know I've laid off the name calling because it's unbecoming. If you'd like to start then I'm happy to but it won't resolve anything.

And an article addressing the risks of ketoacidosis in diabetic patients has sweet buggerall to do with ketones hardening arterial walls. Inflammation, plaque accumulation, and very small, dense ldl particles are primarily responsible for arterial hardening. Ketones play no role in that process whatsoever.

Please cite a single source linking ketones to arterial hardening...
 
sigh when fat breaks down you get a generation of ketone bodies. What happens to the remaining constituents of the fat ? its deposited into the arterial wall cause a hardening of the arteries. These processes work at the same time within the body they are not independent of each other.

find that thread you refering to. I dont recall saying ketones themselves do it. If I did indeed make a mistake then I must fix that information

Anyways ketone bodies lower the pH and cause acidosis. Your body secrets various chemicals to counter this unfortunately these same chemical inhibit the production of proteins that are responsible for elasticity. This is really above you Im not going to waste my time educating you on such complex processes. You also get calcification as there is a degradation of bone. Sometimes its destructive sometimes its protective ... depends on the scenario. This is why they say medicine is not an exact science and Im not about to bring the pinnacle of medical knowledge to people that dont even know basic chemistry, physiology or anatomy

anyways your attempt to discredit me through random nonsense is pointless.

EDIT:

ah this actually reminded me on something I was trying to remember earlier today. off label statin usage in diabetics. For that I thank you
 
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find that thread you refering to. I dont recall saying ketones themselves do it. If I did indeed make a mistake then I must fix that information

Yeah, you did. Here's the quote:

diabetes can cause heart attacks they get a condition known as arteriosclerosis which is a hardening of the arteries , they not flexible anymore so they become stiffer and narrower and if a clot is formed it a big problem (i think they refer to the 'fat' on the inner arterial wall as plague not to sure)... this is due to the high blood sugar levels in the blood and formations of ketones its a very complex biochemical rationale and i don't intend to explain it....

Ketones do not cause hardening of the arteries. That is just a fact...

What happens to the remaining constituents of the fat ? its deposited into the arterial wall cause a hardening of the arteries.

More horsechit. The constituents of the fat don't simply lodge themselves in the arterial walls, willy nilly. High triglycerides can contribute towards arterial wall hardening but certain low density lipoproteins are the root cause of this. Again, not ketones...

Anyways ketone bodies lower the pH and cause acidosis.

True to an extent. But acidosis requires a plasma glucose concentration to be above 250 mg per dL while lower levels with elevated ketone levels is a perfectly healthy state. You're attempting to simplify this to the point that anyone reading it will draw incorrect conclusions, such as elevated ketone levels are always bad...

Your body secrets various chemicals to counter this unfortunately these same chemical inhibit the production of proteins that are responsible for elasticity.

I know of deaminase and triacylglycerol lipase enzymes released but none that I've seen that inhibit titin production, which is the protein you must be referring to. Some more info would be appreciated...

This is really above you Im not going to waste my time educating you on such complex processes.

Oh get over yourself ffs. You're not the be-all and end-all of biology. I've invested a long time in teaching myself this sort of stuff over the years so sod off with your holier-than-thou attitude...

You also get calcification as there is a degradation of bone.

That's a natural process, unless you're referring to blood pH causing further degradation of bones, in which case I can only imagine that this can only be achieved in a state of prolonged ketociadosis. In which case one would have in all likelihood died in such a prolonged state of ketociadosis in any case...

Im not about to bring the pinnacle of medical knowledge to people that dont even know basic chemistry, physiology or anatomy

You are the pinnacle of medical knowledge? And I know nothing about basic chemistry, physiology, or anatomy? Seriously now?

But okay, let's get to your ridiculous triglyceride picture then...

you still havent pointed out the ketone ....

9dfe3a3f64a43cf52d8a0c24a320909c.JPG


My recollection of chemistry is admittedly a little off-base, but in the picture you've provided here, I don't see any bonds that would qualify as being in the ketone group. I do however spot a triglyceride that when broken down will trigger the release of ketones following the breakdown of the methylene and oxygen bonds to allow for the carbonyl group to be bonded to two carbon atoms. I might be wrong, but chemistry is not my strong suit. I do however enjoy learning about the body, which for the most part doesn't require a chemistry degree, and my statement about ketones not causing atherosclerosis has absolutely nothing to do with being able to spot a ketone chemical bond in a glyceride...
 
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As i thought its not incorrect I wasnt really interested in explaining the whole biochemical process of fat break down.

as for the rest of your points. You isolating systems that cannot be isolated dont do that you will never understand how the body works if you do.

not to shabby on the chemistry. The carbonyl is in a sense considered a ketone body not entirely correct to call it that but yeah technicalities. You could classify is as a ketone if you consider the C3H7O3 as a single functional group. It will show on NMR as like a ketone anyways

As for your hardening of arteries WRT to people dying. Diabetic ketoacidosis is a severe complication of uncontrolled diabetes. No body said the pH is maintained perfectly well during treatment. Any form of acidosis will serve to cause calcification due to the enzymes and buffers released by the body and the destruction of bone. Again protective in certain cases destructive in others. Also understand that the coma stage in ketoacidosis does not occur over night it depends on the individual. Some patients for example have had blood sugar levels of 15 to 20 ive seen higher than 20 for weeks, although not indicative for the 'byproducts' of diabetes these processes continue in tandem with each other (since you like to be pedantic in a field of science where you cant be). The blood sugar gives a rough estimate on progression where as the glycated hb will provide a history

LOL you seriously think thats the entire picture I even mentioned plaque formation before then moved on to the biochemical reaction then decided its too much effort to explain it

its a very complex biochemical rationale and i don't intend to explain it....

if you seriously interested for more information with acidosis and calcification of arteries leave me a pm to remind me. When I have time I will share some journal references with you. for now I honestly dont have the time. Though I see how its misleading

EDIT:

for the readers I should say that ketones are not the primary factor of arteriosclerosis. The effect of acidosis in any form WRT to vasculature is not well understood. If there is an effect from ketone body formation its affect would be minor at best though the mechanism of action is not a direct influence of ketone bodies but rather a byproduct by the drop in pH dude to the pka of such ketones bodies

There that clears that up

whats this got to do with fireworks BTW? :confused:
 
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As i thought its not incorrect I wasnt really interested in explaining the whole biochemical process of fat break down.

You still made an incorrect statement about ketones causing arteriosclerosis. It's okay to be wrong...

as for the rest of your points. You isolating systems that cannot be isolated dont do that you will never understand how the body works if you do.

I don't see how I am isolating anything at all. I'm simply addressing each point as it is brought up. If you think that I believe that the various bodily organs and functions act in isolation then you're making a very odd assumption. I am aware of how the major bodily function operate and have a fairly adept understanding of more complex functions and interactions...

not to shabby on the chemistry. The carbonyl is in a sense considered a ketone body not entirely correct to call it that but yeah technicalities.

Well, that's just not true. A carbonyl group is a different chemical classification to a ketone group. While a ketone group will always have a functional carbonyl bond and is an organic carbonyl member, not all carbonyl bonds will be ketones. So ketones are a type of carbonyl group, but carbonyls are not ketones...

You could classify is as a ketone if you consider the C3H7O3 as a single functional group. It will show on NMR as like a ketone anyways

Ah. But it's not. A ketone requires a functional carbonyl group with double carbon bonds. C3H7O3 is a single carbon bond if my chemistry is correct...

As for your hardening of arteries WRT to people dying. Diabetic ketoacidosis is a severe complication of uncontrolled diabetes. No body said the pH is maintained perfectly well during treatment. Any form of acidosis will serve to cause calcification due to the enzymes and buffers released by the body. Again protective in certain cases destructive in others.

The point I was making was that calcification of arterial walls is a minor risk factor in a prolonged state of acidosis, relatively speaking in comparison to more immediate and serious issues associated with prolonged acidosis, especially for diabetics. In addition, it will serve predominantly as a contributive factor to existing inflammation and arterial hardening caused by underlying conditions. Interestingly, only a very, very small part of cholesterol is actually a risk factor for this - very small, dense lipoproteins, and only certain types of LDL. What we know and accept as gospel about cholesterol has slowly been proven to be nonsense and mainstream medicine is beginning to cotton on to high cholesterol and even triglyceride counts not being major causes of cardiovascular disease. In fact the opposite is largely true under certain conditions. Hence the historical under-performance of statin drugs in treating cardiovascular disease. It treats cholesterol, but modern science has proven no causal link between cholesterol and cardiovascular disease other than a very acute LDL group that enable penetration of arterial walls. However the number 1 cause is inflammation, and we now know that this is predominantly brought about by sugar and carbs, not cholesterol, which in fact is an inflammation repairer for the most part...

if you seriously interested for more information with acidosis and calcification of arteries leave me a pm to remind me. When I have time I will share some journal references with you. for now I honestly dont have the time. Though I see how its misleading

I spend a lot of time learning and discussing it on the forum. Find a thread and contribute if you'd like. But I will probably land up telling you're wrong again...

for the readers I should say that ketones are not the primary factor of arteriosclerosis.

Again, that's a bit misleading. Ketones have absolutely no impact on arterial hardening whatsoever. The complications that arise from a state of acidosis may contribute towards elevated risk of complication brought about by existing arteriosclerosis or inflammation. But ketones themselves do not cause them at all, and acidosis is a very dangerous pathological state that is incredibly difficult to achieve if you're not a diabetic. Increasing ketones can be incredibly healthy for you, especially in light of the diet required for elevating ketone levels...

If there is an effect from ketone body formation its affect would be minor at best.

Well no evidence exists that it does. However evidence exists for elevated ketone levels within the nutritional ketogenic constraints having numerous other health benefits, such as efficiency of ATP delivery in the Krebs cycle...
 
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Apologies for bringing this back on topic sort of.....

the law is not subject to your interpretation. If they were one and the same they would not be defined separately

Ummm yes it is, always has been and always will be. The interpretation is set in stone once a judge rules on it


then dont blame the firework

Nobody is, we're blaming the idiots who think they're above the law in regards to the loud fireworks they use



You blame the person down the street because you didnt enclose your animal properly ? ...

I question whether you've ever had dogs with this statement

Im not wrong. Its within the boundaries of the hindu community by law. See loaded question

No its not, plain and simple

Again responsibility of the owner of the sheep to ensure that their enclosure can house them properly and securely. Go on check it up its in the law you lot like to refer to.

Again, should if ever get to a court, the responsibility of the owner will have been met should they have fenced in their property. Responsibility for the loss of sheep and damage to property would rest with the idiot letting off the loud fireworks.

he shouldve had a proper fence

The farmer more than likely did have a proper fence

Nope 2 law modules. 2 written exams and 1 oral per module. Resulting to insults now are we ? shame those also dont work in law, actually hurts your case

Ok, since you did a Bachelor of Pharmacy, and I'm going to assume this was down at UKZN... Health Law and Ethics 1 and Health Law and Ethics 2 do not really qualify you to comment on pretty much any other type of law.

really? im not the one passing recommendations as an act. Again provide the regulations of the act then talk. Thats if you know what regulations are lol

Its a municipal bylaw, it trumps the act in terms of actions in a municipal area.

It is not considered a nuisance firework. Therefore by legality all subsections prohibiting fireworks defined by "nuisance" do not apply to this class of firework. Your subjective opinion again has no bearing

Yes it does unfortunately for you.

ah the infamous 'tablet counter'. If you think this is all a pharmacist does then its no wonder you are battling to understand the law.

I would be surprised if your boss lets you do much else, considering how badly wrong you get so many basic things, which is probably why you have so much time to post on MyBB.

You people prevent racial and cultural cohesion among people. That is why people throw the race card at you. You are no different from people like Malema. Though you too blind to see it

No we don't. You just want to think we do because it suits your very limited world view on the issue.
 
DJ ... you missing the point completely.

You still made an incorrect statement about ketones causing arteriosclerosis. It's okay to be wrong...

its still not wrong lol.

but since you know everything we will leave it at that.
 
I'm gonna put this out there for everyone who may be reading this thread and having a giggle... (cos I sure as hell know it made my morning to read last nights posts)

RiaX and DJ... try to explain the same concept, who's explanation are you more likely to accept?
 
I'm gonna put this out there for everyone who may be reading this thread and having a giggle... (cos I sure as hell know it made my morning to read last nights posts)

RiaX and DJ... try to explain the same concept, who's explanation are you more likely to accept?
IMNSHO DJ's credibility is in a completely different (AND REAL) universe to RiaX's...
 
You NSHO is shared by me as well (Much as I hate to admit that about the traitor).
 
I'm gonna put this out there for everyone who may be reading this thread and having a giggle... (cos I sure as hell know it made my morning to read last nights posts)

RiaX and DJ... try to explain the same concept, who's explanation are you more likely to accept?

Sinbad said:
IMNSHO DJ's credibility is in a completely different (AND REAL) universe to RiaX's...

Yeah, agreed. My own vomit-inducing experience in trying to discuss something with RiaX in another thread was enough to make me snort when I read your question.
 
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