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And finally, nature may be indifferent, but nature as a whole is still a finely tuned engine. Mess with the current settings at your own peril.
Do you not think that we've been messing with natures "settings" since the stone age or even before that? Surely we've been at "war" with nature since we first learned to use tools? Or started selectively breeding other species for food or as tools?
Unless we're going to suddenly decide that the whole thing was a mistake and that we should go back to the trees as nature "intended" until we're wiped out by an asteroid strike, we're going to have to keep messing with the settings until we get it right or until we destroy ourselves.
Nature has been balancing itself for the last 3 billion years. Sure, things have changed, but it has been a slow and gradual process. "Mistakes" have been made, and the price is usually extinction.
My point is that 3 billion years of change is a very long time. Maybe we aren't at our optimum for dealing with the natural enviroment as it is, but personally, I would rather not put my trust in a bunch of know-it-all humans that think they have the answer to all our specieal ills, because if they get it wrong (and seriously, how often do we make mistakes? Nuclear power anyone? Greenhouse gasses? Global warming? etc?), we run a decided risk of extinction.