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I find that a standard Spamassassin installation on my SMTP server gets rid of most.
The big thing about spam is, it has to be clickable and Spamassassin utilises black lists based on known baddy URL's.
That's probably not going to work for very long due to the problem of spoofed domains. The false positive rate is very high with black lists.
Take for example blacklisting <everyone>@mweb.co.za, because you get a few spoofed addresses from that domain like <random-meaningless-characters>@mweb.co.za.
Also you don't have to do anything "unsafe" yourself to have ur address/domain spoofed.
In this case I'm not referring to email addresses that are spoofed, but to the URL's like http://buy.viagra.com which has to be valid to be of use.
I've been running Spamassassin for almost a year, and the false positives are minimal - mostly mail from Yahoogroups.