Wayne Rooney, Rio Ferdinand and Owen Hargreaves will form part of a far stronger Manchester United squad when the Red Devils visit these shores in July to contest the Vodacom Challenge for the second time in three years.
United's Scottish manager Sir Alex Ferguson was in Johannesburg on Tuesday to promote this year's challenge, and was in good humour as he described England's failure to qualify for this year's European Championships as "a big blow to Scotland!"
Well, England's disgrace is also to South African fans' benefit as it means all United's England internationals will be here instead of in Austria and Switzerland.
Indeed, with only five of United's squad away at Euro 2008, Orlando Pirates and Kaizer Chiefs face a much tougher task this time than they did in 2006, when Chiefs walked away with the kudu horn.
Back then, 14 of United's first team squad were absent because of the 2006 World Cup in Germany.
Even United's South American duo of Carlos Tevez and Anderson could make the trip to South Africa, depending on Brazil and Argentina's plans following a June 20 friendly between the two nations.
"I am not sure of their (Brazil and Argentina's) plans. But if they are only playing that friendly, then they will come," said Ferguson.
Pre-season visits to South Africa have proved useful for United in the past. Following their previous two visits to South Africa, in 1993 and 2006, the Red Devils have gone on to win the English league title.
"I hope it will be a good omen again," smiled Ferguson.
United's chances of winning this season's title are, meanwhile, looking slimmer, after Arsenal opened up a five point gap over their rivals on Monday night. Ferguson, however, was unmoved: "There's still a long way to go... it will go down to the wire."
United and Arsenal also meet this weekend in an FA Cup fifth round tie. But Ferguson played down the rivalry. "Any game with Arsenal in the FA Cup should be awesome" he said.
"We have played Arsenal so many times over the years that it is really just another game for us. We won't be fazed by our bad result last Sunday (United lost 2-1 at Old Trafford to local rivals Man City)."
Vodacom Challenge Schedule
July 19: Kaizer Chiefs v Manchester United, Newlands, Cape Town
July 22: Orlando Pirates v Manchester United, Absa Stadium, Durban
July 24: Orlando Pirates v Kaizer Chiefs, Telkom Park, Port Elizabeth
July 26: Manchester United v winner of July 24 match, Loftus Stadium, Pretoria